ID C5XP88_SORBI Unreviewed; 565 AA.
AC C5XP88;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN ORFNames=SORBI_3003G063000 {ECO:0000313|EMBL:EES02429.1};
OS Sorghum bicolor (Sorghum) (Sorghum vulgare).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Sorghinae; Sorghum.
OX NCBI_TaxID=4558 {ECO:0000313|EMBL:EES02429.1, ECO:0000313|Proteomes:UP000000768};
RN [1] {ECO:0000313|EMBL:EES02429.1, ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=19189423; DOI=10.1038/nature07723;
RA Paterson A.H., Bowers J.E., Bruggmann R., Dubchak I., Grimwood J.,
RA Gundlach H., Haberer G., Hellsten U., Mitros T., Poliakov A., Schmutz J.,
RA Spannagl M., Tang H., Wang X., Wicker T., Bharti A.K., Chapman J.,
RA Feltus F.A., Gowik U., Grigoriev I.V., Lyons E., Maher C.A., Martis M.,
RA Narechania A., Otillar R.P., Penning B.W., Salamov A.A., Wang Y., Zhang L.,
RA Carpita N.C., Freeling M., Gingle A.R., Hash C.T., Keller B., Klein P.,
RA Kresovich S., McCann M.C., Ming R., Peterson D.G., Mehboob-ur-Rahman,
RA Ware D., Westhoff P., Mayer K.F., Messing J., Rokhsar D.S.;
RT "The Sorghum bicolor genome and the diversification of grasses.";
RL Nature 457:551-556(2009).
RN [2] {ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=29161754; DOI=10.1111/tpj.13781;
RA McCormick R.F., Truong S.K., Sreedasyam A., Jenkins J., Shu S., Sims D.,
RA Kennedy M., Amirebrahimi M., Weers B.D., McKinley B., Mattison A.,
RA Morishige D.T., Grimwood J., Schmutz J., Mullet J.E.;
RT "The Sorghum bicolor reference genome: improved assembly, gene annotations,
RT a transcriptome atlas, and signatures of genome organization.";
RL Plant J. 93:338-354(2018).
CC -!- FUNCTION: Binds specifically and directly to substrates containing
CC either a simple or bipartite NLS motif. Promotes docking of import
CC substrates to the nuclear envelope. {ECO:0000256|PIRNR:PIRNR005673}.
CC -!- SUBUNIT: Forms a complex with importin subunit beta-1.
CC {ECO:0000256|PIRNR:PIRNR005673}.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM000762; EES02429.1; -; Genomic_DNA.
DR RefSeq; XP_002457309.1; XM_002457264.1.
DR AlphaFoldDB; C5XP88; -.
DR STRING; 4558.C5XP88; -.
DR EnsemblPlants; EES02429; EES02429; SORBI_3003G063000.
DR GeneID; 8059116; -.
DR Gramene; EES02429; EES02429; SORBI_3003G063000.
DR KEGG; sbi:8059116; -.
DR eggNOG; KOG0166; Eukaryota.
DR HOGENOM; CLU_516194_0_0_1; -.
DR InParanoid; C5XP88; -.
DR OMA; QMRNMAN; -.
DR OrthoDB; 1219011at2759; -.
DR Proteomes; UP000000768; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF89; IMPORTIN SUBUNIT ALPHA-9; 1.
DR Pfam; PF00514; Arm; 3.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 6.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Reference proteome {ECO:0000313|Proteomes:UP000000768};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 565 AA; 60836 MW; 944F8AC2192E769A CRC64;
MPVSVPFAYI TKQPRTRVRE KKNSSRRAQP PRPGPGKMAD GSASASPPSV SPHHQYHRDA
IKSSVRNTAA NRRREQALAI GKERREALMR AKRVCRAPLS GSDEAAAEDG DMVTDEGKAD
LEARTTQAVE ELKSALSSQG KGAQKRKTEV LRALRRLLSQ SEVPPVDAAI KAGAVPLLVQ
YLSFGSSDEQ LLEAAWCLTN IAAGEPEETK SLLPALPLLI AHLGEKSSTL VAEQCAWAIG
NVAGEGAELR STLLAQGALW PLARLMLSNK GSTARTAAWA LSNLIKGPDS KAANELIGID
GVLNAITRNL EKADEELATE VAWVVVYLSA LSEKATSQIV RSSVPLLLIG RLLASENLQL
LIPVLRGLGN LVAGDGYMVD SVLTVGNSVT DQALASLIKC LKSDNRVLKK EASWAMSNVA
AGSFEHKKLI FASEATPLLM HLLRTAQFDI RREAAYTLGN LCVVPAGSGN PPNIIVDHLV
AIVDGGGLPG FINLVRSADI ESARLGLQFL ELVMRGYPNN QGPKLVERED GIEAMERFQF
HENEVMRNMA NGLVDKYFGE DYGLE
//
