ID C5YAF6_SORBI Unreviewed; 1045 AA.
AC C5YAF6;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=C2 and GRAM domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=SORBI_3006G119600 {ECO:0000313|EMBL:EES10990.2};
OS Sorghum bicolor (Sorghum) (Sorghum vulgare).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Sorghinae; Sorghum.
OX NCBI_TaxID=4558 {ECO:0000313|EMBL:EES10990.2, ECO:0000313|Proteomes:UP000000768};
RN [1] {ECO:0000313|EMBL:EES10990.2, ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=19189423; DOI=10.1038/nature07723;
RA Paterson A.H., Bowers J.E., Bruggmann R., Dubchak I., Grimwood J.,
RA Gundlach H., Haberer G., Hellsten U., Mitros T., Poliakov A., Schmutz J.,
RA Spannagl M., Tang H., Wang X., Wicker T., Bharti A.K., Chapman J.,
RA Feltus F.A., Gowik U., Grigoriev I.V., Lyons E., Maher C.A., Martis M.,
RA Narechania A., Otillar R.P., Penning B.W., Salamov A.A., Wang Y., Zhang L.,
RA Carpita N.C., Freeling M., Gingle A.R., Hash C.T., Keller B., Klein P.,
RA Kresovich S., McCann M.C., Ming R., Peterson D.G., Mehboob-ur-Rahman,
RA Ware D., Westhoff P., Mayer K.F., Messing J., Rokhsar D.S.;
RT "The Sorghum bicolor genome and the diversification of grasses.";
RL Nature 457:551-556(2009).
RN [2] {ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=29161754; DOI=10.1111/tpj.13781;
RA McCormick R.F., Truong S.K., Sreedasyam A., Jenkins J., Shu S., Sims D.,
RA Kennedy M., Amirebrahimi M., Weers B.D., McKinley B., Mattison A.,
RA Morishige D.T., Grimwood J., Schmutz J., Mullet J.E.;
RT "The Sorghum bicolor reference genome: improved assembly, gene annotations,
RT a transcriptome atlas, and signatures of genome organization.";
RL Plant J. 93:338-354(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
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DR EMBL; CM000765; EES10990.2; -; Genomic_DNA.
DR AlphaFoldDB; C5YAF6; -.
DR STRING; 4558.C5YAF6; -.
DR EnsemblPlants; EES10990; EES10990; SORBI_3006G119600.
DR Gramene; EES10990; EES10990; SORBI_3006G119600.
DR eggNOG; KOG1032; Eukaryota.
DR HOGENOM; CLU_086483_0_0_1; -.
DR InParanoid; C5YAF6; -.
DR OMA; QKYRIAN; -.
DR OrthoDB; 590187at2759; -.
DR Proteomes; UP000000768; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00030; C2; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR044511; At1g03370/At5g50170-like.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR031968; VASt.
DR PANTHER; PTHR46296; BNAA05G37250D PROTEIN; 1.
DR PANTHER; PTHR46296:SF7; C2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF16016; VASt; 2.
DR SMART; SM00239; C2; 2.
DR SMART; SM00568; GRAM; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS51778; VAST; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000768};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 476..498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..114
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 276..449
FT /note="VASt"
FT /evidence="ECO:0000259|PROSITE:PS51778"
FT DOMAIN 542..660
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 876..1036
FT /note="VASt"
FT /evidence="ECO:0000259|PROSITE:PS51778"
FT REGION 107..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1045 AA; 116048 MW; 1A5597B86A9EABF6 CRC64;
MRLYVYVLEA RGLPAPRPRR GGGVLFYAKV TVGKQRFRTR AVEAAELDGG AAAAWNEEFV
FAVGAADGAA GDDEEFEVAV ARRRRGGGSG REVVGKVRLP VPPAATAAAA PGERRSVPPT
WFTLQQPPEG GRGRRKRGVV VDEVAAADCG KILLSFSLYG ENNDNSVVHM SPSSSSRSYT
DAEVERSLDM EHSSSNGEVV DSPRSHDTER TSLDNSDHFI HEDSNSITEV DDLAETSTAT
ANGASDTEHM APDASFEEAM EIMKSRSTPE MPEDLDGGII FEHTYLVESK ELNHLLFRPD
SQFLKGLREL QGTMDYEEQP WTWKSMDPPS LTRTCHYTKG ASKFMKAVKT SEEQTYLKAD
GKNFVIMTRV RTPEVPFGNC FAVVLLYKII HCTGLSGGEE SAHLTVSYNV EFLQSTMMRS
MIEGSVRDGL KENFEGFAEV LSRHVKMADS VGMDKEQLLA PLQVEHQSDI RLAYKYFFNF
TAISTVLFAL YVLVHIFLSK PGPIMGLEFN GLDLPDSFGE LITAGILVLQ LQRLLNMVSH
FVLARLQRGS DHGVKANGDG WLLTVALLEA TSLPPVSCGS VDPYVVFSCN GITRTSSVQL
QTQEPQWNEI MEFDAMEEPP AVLDVEVFNF DGPFDLAISL GHAEINFLKH TSVELADIWV
PLEGKLAQTC QSRLHLRVFL ENTKGPETSM REYLSKMEKE VGKKLHVRSP HRNSTFQKLF
NLPHEEFLIA DYACSLKRKL PLQGRLFVSA RIVGFYANLF GHKTKFFFLW EDVEEIEVLQ
PSFTTVGTPS LLFILKSGRG LDAKSGAKSQ DKEGRLKFQF HSFASFSKAS RTIIGLWKTK
SSAIEHRAKL EEDHEEDASS VDLDEVQAVL SIGDVPLSKE YTLEHPIDAD LLMGVFDGGA
LETRTMSRVG CLDYSATPWE AVRPGVLERH VSYKFNRYMS IFGGEVVSTQ LKFPAEDGGG
WTIHDVVTLH NVPFGDYFRV HLRYNVQSAT SEAPSSRCEI LVGIEWLKSS KFQKRIARNI
CEKLAHRAKE VLEVAGKEIA SAVSG
//
