ID   C5ZWY9_9HELI            Unreviewed;       919 AA.
AC   C5ZWY9;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=HCAN_0943 {ECO:0000313|EMBL:EES89657.1};
OS   Helicobacter canadensis MIT 98-5491.
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=537970 {ECO:0000313|EMBL:EES89657.1, ECO:0000313|Proteomes:UP000007032};
RN   [1] {ECO:0000313|EMBL:EES89657.1, ECO:0000313|Proteomes:UP000007032}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 13241 {ECO:0000313|Proteomes:UP000007032};
RX   PubMed=19542273; DOI=10.1128/JB.00729-09;
RA   Loman N.J., Snyder L.A., Linton J.D., Langdon R., Lawson A.J.,
RA   Weinstock G.M., Wren B.W., Pallen M.J.;
RT   "Genome sequence of the emerging pathogen Helicobacter canadensis.";
RL   J. Bacteriol. 191:5566-5567(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; CM000776; EES89657.1; -; Genomic_DNA.
DR   RefSeq; WP_006656860.1; NZ_CM000776.2.
DR   AlphaFoldDB; C5ZWY9; -.
DR   STRING; 537970.HCAN_0943; -.
DR   eggNOG; COG1074; Bacteria.
DR   HOGENOM; CLU_010638_1_0_7; -.
DR   OrthoDB; 9810135at2; -.
DR   Proteomes; UP000007032; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF64; ATP-DEPENDENT DNA HELICASE REP; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 2.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000007032}.
FT   DOMAIN          1..414
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   BINDING         10..17
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   919 AA;  107331 MW;  EC640FF308E8831F CRC64;
     MENALLCLNA SAGSGKTYRL VLRYLELLFL GAKPSEILTL TFTKKAAKEM EERIVKSIQE
     IYQRKNDREY IKKLEFISIN DLEGIEQKIT KIYYEFLRED LKITTIDSFF QRILKSFCWY
     VGVENNFEIQ NEDFEIITEI FLELLSDEAF ERIVVFCVQG RKNINSVLSL CFFLDSFKEM
     LDKELFVYEA PKGDKEQVME YAYRLQREYK KSKGESKSKT SNPMDFSDFN SLLHKGKTWL
     TKEKITDFKG FGKIPFDERD FEGLKEALLE VYLDDESQYL KNLYEIFQVY LQAKEKYYQQ
     SNTLSFNAVT SKVYELLLKK NFDKEFLYFR LDSTISHILI DEFQDTSILQ YEILKPMIDE
     IKSGKGVKEF LRSFFYVGDI KQSIYRFRGG NPNLFKIAAD GMKQESLQKN YRSAKNLVEF
     VNEVFSNKID GFVSQEANSH YEGFVRVVIN EADKQEISKC LRELLELGAK EEEIAILLFD
     NDWVVELAEF LETDGFKVVM DTSAKLVFHN EVRALIEFLK YLDSKNPQFC EEFFMLLGLE
     KESLDRYFEI LENPPAVILL QVMQFFKISS LSAKKFLEYA LGFASVGELL EKVESLQADI
     VSSECSGIRL MTIHKSKGLE FNHVLVIDDN KARSRYNNVF FEFKENGVEI QRVFQKSNDL
     RKSLDKTYQK AILKEEILKE KDLKNQLYVA LTRAKNTMHI MLLSEKGRFD SLGLESLQRG
     DLKSALEEIK DAINLPKKEE RVFFEEASYK RSLEALGTQK KMQVIQKEVQ EGKIQGIYYG
     VALHFVMEQK IKNNLDDLVL LEILCNKMGF LMERESLENV IKHCKKILKN SHFIEILTKG
     KVKCEIPFLS NGRQKRLDLL VIGENEAFVI DYKSGMQRES YMTQVLEYMQ SVEEILQKPT
     RGFVFYTEGE GRLVEVIGE
//