ID C5ZXI3_9HELI Unreviewed; 702 AA.
AC C5ZXI3;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=pcrA {ECO:0000313|EMBL:EES89851.1};
GN ORFNames=HCAN_1140 {ECO:0000313|EMBL:EES89851.1};
OS Helicobacter canadensis MIT 98-5491.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=537970 {ECO:0000313|EMBL:EES89851.1, ECO:0000313|Proteomes:UP000007032};
RN [1] {ECO:0000313|EMBL:EES89851.1, ECO:0000313|Proteomes:UP000007032}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 13241 {ECO:0000313|Proteomes:UP000007032};
RX PubMed=19542273; DOI=10.1128/JB.00729-09;
RA Loman N.J., Snyder L.A., Linton J.D., Langdon R., Lawson A.J.,
RA Weinstock G.M., Wren B.W., Pallen M.J.;
RT "Genome sequence of the emerging pathogen Helicobacter canadensis.";
RL J. Bacteriol. 191:5566-5567(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CM000776; EES89851.1; -; Genomic_DNA.
DR RefSeq; WP_006655846.1; NZ_DS990368.1.
DR AlphaFoldDB; C5ZXI3; -.
DR STRING; 537970.HCAN_1140; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_004585_5_2_7; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000007032; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000007032}.
FT DOMAIN 7..281
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 282..561
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 28..35
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 702 AA; 80722 MW; D2ACFA477473BAA5 CRC64;
MQEKFLNQLN TSQKQAVTTI EGALLILAGA GSGKTKTITT RLAYLIDEVG IPPSNTLTLT
FTNKAANEMQ KRALNMLKKS TSHPPLLCTF HKFGLLFLKF YISLLGRKIN FILADSDDTK
KILKELNCDL APLPLIISEI SRYKNSQITP QEALKNAHNE LYKHIAKVYL NYQETLLQNN
MVDFDDLLLL PIEILKSNPN VATEISQKYQ YIMVDEYQDT NDLQYQLLKY LCTTHNNICV
VGDDDQSIYS WRGANIQNIL NFSQHFKGAK TIKLEENYRS SKSILNAANH LISNNKERLG
KTLKSTLDEG KPIEVLHSYD EQEEAKNLSK IIKKLLQNGI NPKDIAILFR LNALSRSLEE
GFNRERIPYV LVGTIRFYER SEIKDVISYF RVLTNINDDF SLLRIINKPK RGIGKTTLEK
LKSLSQIHHC SIYELFSNQS PQLLQQEISK KTYNTIWEFF KTIKELQDLQ AQSSLKFLDD
FEEKIGLCKA LSQNSEEVDR VSNIEEFYGL YREYVKQNPL MELEDFLNEL ALRSDQEDTE
LRNEQKGVEG VSCMSVHSSK GLEFDYVFII GLEEGFFPMA REDTNLQEER RLGYVAFTRA
KKELYLSYVD SRFYRGNRTS LYPSRFLAES KILAKENFLN QNTTDISKTA YEIGFQRGDC
VMHKIFGAGR ITEITKSGQE IKLKINFGGL LREILSGYVT KV
//
