ID C6A030_THESM Unreviewed; 365 AA.
AC C6A030;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Predicted N6-adenine-specific DNA methylase {ECO:0000313|EMBL:ACS91011.1};
GN OrderedLocusNames=TSIB_1962 {ECO:0000313|EMBL:ACS91011.1};
OS Thermococcus sibiricus (strain DSM 12597 / MM 739).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=604354 {ECO:0000313|EMBL:ACS91011.1, ECO:0000313|Proteomes:UP000009079};
RN [1] {ECO:0000313|EMBL:ACS91011.1, ECO:0000313|Proteomes:UP000009079}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12597 / MM 739 {ECO:0000313|Proteomes:UP000009079};
RX PubMed=19447963; DOI=10.1128/AEM.00718-09;
RA Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V.,
RA Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.;
RT "Metabolic versatility and indigenous origin of the archaeon Thermococcus
RT sibiricus, isolated from a siberian oil reservoir, as revealed by genome
RT analysis.";
RL Appl. Environ. Microbiol. 75:4580-4588(2009).
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DR EMBL; CP001463; ACS91011.1; -; Genomic_DNA.
DR AlphaFoldDB; C6A030; -.
DR STRING; 604354.TSIB_1962; -.
DR KEGG; tsi:TSIB_1962; -.
DR eggNOG; arCOG00048; Archaea.
DR HOGENOM; CLU_032119_0_0_2; -.
DR Proteomes; UP000009079; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006400; P:tRNA modification; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11715; THUMP_AdoMetMT; 1.
DR Gene3D; 3.30.2130.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR004114; THUMP_dom.
DR NCBIfam; NF040850; Trm14_Thcoccales; 1.
DR PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14911:SF22; TRNA (GUANINE(6)-N2)-METHYLTRANSFERASE; 1.
DR Pfam; PF02926; THUMP; 1.
DR Pfam; PF01170; UPF0020; 1.
DR SMART; SM00981; THUMP; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF143437; THUMP domain-like; 1.
DR PROSITE; PS51165; THUMP; 1.
DR PROSITE; PS01261; UPF0020; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ACS91011.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000009079};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW Transferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000313|EMBL:ACS91011.1}.
FT DOMAIN 72..182
FT /note="THUMP"
FT /evidence="ECO:0000259|PROSITE:PS51165"
SQ SEQUENCE 365 AA; 41035 MW; 9218E9A6D3B84C6B CRC64;
MKKMKFVLTT PQGIEDLAKR EVEMLIKSAG LKGKVEEKPS GVEGRILAEI EESYYLDEKG
KKREFEIASF LNENSRLLHR VIFQLSSTKL SNLEKEKALQ EIYDFVSNSL IENYVKISES
FAVRGFRKGE HEFTSIDVAK TVGSAIYDKL SKFGTPKVNL DHPSVIFRAE VINDVFFLGI
DTTGDSSLHK RPWRVYDHPA HLKASIANAM IELAELDEGS VLDPMCGSGT ILIELALRGY
EGKIIGIEKY KKHLKGAMMN ALAAGVLDKI DLIQGDATRL SHYLDSVDFV ISNLPYGLKI
GKKKLIPELY MKFFAELSKI LGKRGVFLTT EKKAIEKAFE ENGFKIIHHR LVGHGGLMVH
LYIIK
//
