ID C6GAA3_AERHY Unreviewed; 503 AA.
AC C6GAA3;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=pRA1_0146 {ECO:0000313|EMBL:ACN67033.1};
OS Aeromonas hydrophila.
OG Plasmid pRA1 {ECO:0000313|EMBL:ACN67033.1}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
OC Aeromonadaceae; Aeromonas.
OX NCBI_TaxID=644 {ECO:0000313|EMBL:ACN67033.1};
RN [1] {ECO:0000313|EMBL:ACN67033.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=pRA1 {ECO:0000313|EMBL:ACN67033.1};
RX PubMed=19482926; DOI=10.1128/JB.00189-09;
RA Fricke W.F., Welch T.J., McDermott P.F., Mammel M.K., LeClerc J.E.,
RA White D.G., Cebula T.A., Ravel J.;
RT "Comparative genomics of the IncA/C multidrug resistance plasmid family.";
RL J. Bacteriol. 191:4750-4757(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; FJ705807; ACN67033.1; -; Genomic_DNA.
DR RefSeq; WP_012766370.1; NC_012885.1.
DR RefSeq; YP_002995644.1; NC_012885.1.
DR AlphaFoldDB; C6GAA3; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF30; F-BOX DNA HELICASE 1; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Plasmid {ECO:0000313|EMBL:ACN67033.1}.
FT DOMAIN 5..260
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 26..33
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 503 AA; 57418 MW; AA53295F2C0CCCC0 CRC64;
MKQLPRDTPE QSLITQYKGS RLVVKAYAGT GKTTTLVKYA HNNLDSRILY LAYNRAIRDE
AREKFPANVD CKTSHQLAYA TIGRGYHHKL TGNLRLTDIA QAVNTKNWTF AKDILDTLNA
FMCSADMRIL YTHFARADTG KVLTSKQERY QIQVVEGAEL IWKRMTNLQD PFPTVHDCYL
KQYQLGMPNL SRRYTTILFD EAQDANPVTS SIVLQQKCKV ILVGDRHQQI YRFRGANNAL
DSKELMNADQ LYLTHSFRFG PNVSLVANAL LELKGETRPV VGRGPADQVV MFLPGDVGHR
AILHRTVMGV IETALSATES GSQVFWVGGI DAYQINELQD LYWFSMAEPD RVKNKKLLDE
YEDYFEYQEV AKATKDPEMM RAVKIISSYD EIPERLTTLR RNTVKEEFGA DITVSTAHRC
KGLEWDFVQL YDDFPDVLDP ELDPMARDDE INLLYVASTR AMRILALNSA VEMVIRYITQ
KRMVEKQMKM AAMATEVEGN TTK
//
