ID C6GBY8_ONCMY Unreviewed; 214 AA.
AC C6GBY8;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Insulin-like growth factor II {ECO:0000313|EMBL:ACS83575.1};
GN ORFNames=GSONMT00079535001 {ECO:0000313|EMBL:CDQ59275.1};
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022 {ECO:0000313|EMBL:ACS83575.1};
RN [1] {ECO:0000313|EMBL:ACS83575.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Muscle {ECO:0000313|EMBL:ACS83575.1};
RX PubMed=9701612;
RA Shamblott M.J., Leung S., Greene M.W., Chen T.T.;
RT "Characterization of a teleost insulin-like growth factor II (IGF-II) gene:
RT evidence for promoter CCAAT/enhancer-binding protein (C/EBP) sites, and the
RT presence of hepatic C/EBP.";
RL Mol. Mar. Biol. Biotechnol. 7:181-190(1998).
RN [2] {ECO:0000313|EMBL:ACS83575.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Muscle {ECO:0000313|EMBL:ACS83575.1};
RX PubMed=20228168; DOI=10.1210/en.2009-0960;
RA Lo J.H., Chen T.T.;
RT "CCAAT/enhancer binding protein beta2 is involved in growth hormone-
RT regulated insulin-like growth factor-II gene expression in the liver of
RT rainbow trout (Oncorhynchus mykiss).";
RL Endocrinology 151:2128-2139(2010).
RN [3] {ECO:0000313|EMBL:CDQ59275.1, ECO:0000313|Proteomes:UP000193380}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24755649; DOI=10.1038/ncomms4657;
RA Berthelot C., Brunet F., Chalopin D., Juanchich A., Bernard M., Noel B.,
RA Bento P., Da Silva C., Labadie K., Alberti A., Aury J.M., Louis A.,
RA Dehais P., Bardou P., Montfort J., Klopp C., Cabau C., Gaspin C.,
RA Thorgaard G.H., Boussaha M., Quillet E., Guyomard R., Galiana D., Bobe J.,
RA Volff J.N., Genet C., Wincker P., Jaillon O., Roest Crollius H.,
RA Guiguen Y.;
RT "The rainbow trout genome provides novel insights into evolution after
RT whole-genome duplication in vertebrates.";
RL Nat. Commun. 5:3657-3657(2014).
RN [4] {ECO:0000313|EMBL:CDQ59275.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR EMBL; FJ817293; ACS83575.1; -; Genomic_DNA.
DR EMBL; FR904321; CDQ59275.1; -; Genomic_DNA.
DR RefSeq; NP_001118169.1; NM_001124697.1.
DR AlphaFoldDB; C6GBY8; -.
DR STRING; 8022.C6GBY8; -.
DR PaxDb; 8022-C6GBY8; -.
DR GeneID; 100136742; -.
DR KEGG; omy:100136742; -.
DR CTD; 324215; -.
DR OrthoDB; 5402912at2759; -.
DR Proteomes; UP000193380; Chromosome 2.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR CDD; cd04368; IlGF; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR022334; IGF2.
DR InterPro; IPR013576; IGF2_C.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR022350; Insulin-like_growth_factor.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR46886; INSULIN-LIKE GROWTH FACTOR II; 1.
DR PANTHER; PTHR46886:SF1; INSULIN-LIKE GROWTH FACTOR II; 1.
DR Pfam; PF08365; IGF2_C; 1.
DR Pfam; PF00049; Insulin; 2.
DR PRINTS; PR02002; INSLNLIKEGF.
DR PRINTS; PR02006; INSLNLIKEGF2.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR622350-50};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Reference proteome {ECO:0000313|Proteomes:UP000193380};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406}.
FT DOMAIN 53..110
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT DISULFID 56..97
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 68..110
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 96..101
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
SQ SEQUENCE 214 AA; 24637 MW; FF8CCB173314C8FA CRC64;
METQKRHEYH SVCHTCRRTE NTRMKVKMMS SSNRVLVIAL ALTLYIVEVA SAETLCGGEL
VDALQFVCED RGFYFSRPTS RSNSRRSQNR GIVEECCFRS CDLNLLEQYC AKPAKSERDV
SATSLQIIPM VPTIKQDVPR KHVTVKYSKY EAWQRKAAQR LRRGVPAILR ARKFRRQAVK
IKAQEQAMFH RPLITLPSKL PPVLPPTDNY VSHN
//
