ID   C6H2Y7_AJECH            Unreviewed;       531 AA.
AC   C6H2Y7;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Aldehyde dehydrogenase {ECO:0000256|PIRNR:PIRNR036492};
GN   ORFNames=HCDG_01069 {ECO:0000313|EMBL:EER45490.1};
OS   Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=544712 {ECO:0000313|EMBL:EER45490.1, ECO:0000313|Proteomes:UP000002624};
RN   [1] {ECO:0000313|Proteomes:UP000002624}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA   Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA   Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain H143.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00009986, ECO:0000256|PIRNR:PIRNR036492}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG692419; EER45490.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6H2Y7; -.
DR   STRING; 544712.C6H2Y7; -.
DR   VEuPathDB; FungiDB:HCDG_01069; -.
DR   eggNOG; KOG2456; Eukaryota.
DR   HOGENOM; CLU_005391_3_1_1; -.
DR   OMA; EIDWCKQ; -.
DR   Proteomes; UP000002624; Unassembled WGS sequence.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006081; P:cellular aldehyde metabolic process; IEA:InterPro.
DR   CDD; cd07135; ALDH_F14-YMR110C; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR012394; Aldehyde_DH_NAD(P).
DR   PANTHER; PTHR43570; ALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43570:SF11; ALDEHYDE DEHYDROGENASE; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PIRSF; PIRSF036492; ALDH; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR036492};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002624}.
FT   DOMAIN          15..443
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        224
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036492-1"
FT   ACT_SITE        258
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036492-1"
SQ   SEQUENCE   531 AA;  58600 MW;  A7FB401FD673FB12 CRC64;
     MATVDLPTLQ FTPVEEIPAK VRKVRTTFFQ HKTRPIEFRM QQLRKLYWAL KDREHLVVEA
     LYRDLGKPKY ETYVSEINIV ENDIVFIQKN VAKWAKDEKA QNIDMPFTLM KPRIRKDPLG
     CVLVIGAFNV PFSLNILPLI GAIAAGNTVV VKPSESSPNC AAVLQEIIEA AIDPDVVSVV
     QGGATETQAL LAERWDKICF TGNATVGRIV AQAAAPNLTP VLLELGGRNP AFITKKADVR
     LAARRLFWAK TFNAGQICLS QNYILVDKEI VSQLVTEFGK VWKEFYPDGV KASPDFCRII
     NDAAFRRIKD MIDSTKGKIL LGGTMDEKER FIEPTLVQVD SADDPLVRWE TFGPIITILP
     VGDLDEAIRI SNDVDNTPLA AYAFGTKKEV EKVLSCVRSG GATINDTYMH GIIPNVPFGG
     VGESGSGAYH GRSSFDAFVH RRSIATTPGW VERMLSVRYP PYAGKLRSTL RSGTVAPNFD
     RSGRTTTGFW GWIIWFITFG GGANKSGASR AAVAVVAAIA LNYYIKRGVK V
//