ID C6H678_AJECH Unreviewed; 612 AA.
AC C6H678;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=AMP dependent ligase {ECO:0000313|EMBL:EER43899.1};
GN ORFNames=HCDG_01929 {ECO:0000313|EMBL:EER43899.1};
OS Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544712 {ECO:0000313|EMBL:EER43899.1, ECO:0000313|Proteomes:UP000002624};
RN [1] {ECO:0000313|Proteomes:UP000002624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain H143.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; GG692420; EER43899.1; -; Genomic_DNA.
DR AlphaFoldDB; C6H678; -.
DR STRING; 544712.C6H678; -.
DR VEuPathDB; FungiDB:HCDG_01929; -.
DR HOGENOM; CLU_000022_46_3_1; -.
DR OMA; RDTRGHC; -.
DR Proteomes; UP000002624; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43107:SF6; ACYL-COA SYNTHETASE FAMILY PROTEIN (CEFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03630)-RELATED; 1.
DR PANTHER; PTHR43107; LONG-CHAIN FATTY ACID TRANSPORT PROTEIN; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:EER43899.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002624}.
FT DOMAIN 122..258
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 478..556
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
FT REGION 553..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..576
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 612 AA; 68899 MW; 77465B76C77E8AF3 CRC64;
MTENATLLAE NVWATVLEIG VEVNNLSTSS KSGLRPVESL PRQNGVPPAN GFGWISLSYG
DEPRISQFTA AAAVAGVGAL GAYLDGKYQL RRDAYTIHRM RRSERIAARA KAEGRLNVWY
VFRNVVEKYP NALCVWSRTG SYTFREVLDI SCQYGNYFLS IGVKRGRLVA FYLQNSPEFV
FVWLGLWSIG CGPAMINYNL TEAGLIHCLK LSGADVIVVD ADAECTARIH DQRNEIENDL
KMHSVHNGAA QRMRVYYESD VYHDLPEKIY ATEKVMEATG ACILTGVSVA IAKKFSTSRF
WKDIHDSKSI YVGETARHLL TAPPSPLDRG HNVRCMYGNG LRPDVWEKFK ERGPYQSRCV
GHHGAILRRL MHNVYIPVVI DPMTGDMYRD PKTGFATRAP YSEGGEIIIS VPDESAFQGY
WKNPDATAKK FVRDVFKKGD IYYRTGDALR RTDDGHWHFL DRLGDTFRWK SENVSTAEVA
TVLGEYPGVA EANVYGVSVP THEGRAGCAA ILIQPDQRFN FGFAAFARYA RERLPKYAVP
VFLRLVEASN HTHNQKQNKV PLRDEGVDPD KLGSKAREGK NDRFLWLLPQ NDTYLEFGRS
DWEDLVNGRV KL
//
