ID C6H7R8_AJECH Unreviewed; 1006 AA.
AC C6H7R8;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 03-MAY-2023, entry version 51.
DE SubName: Full=PX domain-containing protein {ECO:0000313|EMBL:EER43449.1};
GN ORFNames=HCDG_01479 {ECO:0000313|EMBL:EER43449.1};
OS Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544712 {ECO:0000313|EMBL:EER43449.1, ECO:0000313|Proteomes:UP000002624};
RN [1] {ECO:0000313|Proteomes:UP000002624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain H143.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; GG692420; EER43449.1; -; Genomic_DNA.
DR AlphaFoldDB; C6H7R8; -.
DR STRING; 544712.C6H7R8; -.
DR VEuPathDB; FungiDB:HCDG_01479; -.
DR eggNOG; ENOG502RM76; Eukaryota.
DR HOGENOM; CLU_007315_0_0_1; -.
DR OMA; INGWIIH; -.
DR Proteomes; UP000002624; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06093; PX_domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775:SF47; MEIOTICALLY UP-REGULATED GENE 122 PROTEIN; 1.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR SMART; SM00313; PXA; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS51207; PXA; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002624};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 73..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 161..343
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 752..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..766
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..790
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1006 AA; 109904 MW; 70843B39B24AC1E3 CRC64;
MDGCQLDETT DDSVSVGDST PSGPPQDPAA CTVDATSSSP SIARHSPLLD QCLQFLSAAN
NATLAALGGV TIAITYFVLG RLSLVLFGVV AGIGLHSSWE GYKEYGDEST KAGPSIRRRE
LGIEVAKRLL NWEESRTTDK PRYQASPEDM SMTKLDYSDF QPATAAALNT LTDAVIRDYV
QWWYQPILSS EQTFPQSCRS TLARFVISIS SHLSRKRPAD IFLHFVTNAS SIIIVFLNEL
SSALQSTSSG PASTADAIST YLNRFPESNL ANVLSTTQQR AKLRLVASDL LQTFLQPDLY
DCEPVRVFLC EILSGVILES VIDNCSKPEW INGWIVQLLE EGEPELMSAI DIGVDGARQN
NLEEFSTHSL AANNNMPDFA DDSRTSQQNQ GLTKAQIEME EAVREAKRLS AMIESGSTRG
YQEQPSTIVT DGDIDIRHAS FSSKISHVET TASSDGVWIG NVTTRHGDVS RSSNELGDSR
NSMDEPRSIQ EASIRMILLG ASVSIFDDNS SNDKGAMRVK PTDDYLLQIE PASSRHPGWV
ITRKYADFEV LHEVLRRISV VSGVSDFVEQ HRELPTWKGQ YQSDLRQSLE RYLQHALRFE
RLAGCEAMKR FLEKERSVAT SSPNGIGKSG FSFPSQAVFE NMGKGVLEVL SSAPKGVAGG
GKAVLEGVTG VFGAGSSVKK RSVDFALRDK VDPKLRMPPN GFFNNKVAIS QNSGGTAEMA
SPSRPDTEHY IPLGSGSIEN AFEKPLTYVT HEDAEENEEE QSVFKRPVAD RLSPSLSPEH
SGQNQENGPV ASKNRLQEVE PISTGLAGQV TGFNGNTAVQ PESDVESLNS HLNPDSTEVR
VMPLSEEETG VAVELLFAVI NELYALSSAW GIRKKLLNAA RSFLLRPGNP NIEGIRLLMQ
QSIIESNASD DALATYITAL RQNALPTEDE LKSIHPPLTD DEQMELRIKA RKLLVTRGMP
RALTSIMGNA ATTEALGHVF DSLQVKSVAR GFIFAFLLQA LKAMIQ
//
