ID   C6HGR6_AJECH            Unreviewed;       534 AA.
AC   C6HGR6;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=6-phosphofructo-2-kinase {ECO:0000313|EMBL:EER40568.1};
GN   ORFNames=HCDG_05157 {ECO:0000313|EMBL:EER40568.1};
OS   Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=544712 {ECO:0000313|EMBL:EER40568.1, ECO:0000313|Proteomes:UP000002624};
RN   [1] {ECO:0000313|Proteomes:UP000002624}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA   Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA   Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain H143.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GG692426; EER40568.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6HGR6; -.
DR   STRING; 544712.C6HGR6; -.
DR   VEuPathDB; FungiDB:HCDG_05157; -.
DR   HOGENOM; CLU_006383_0_2_1; -.
DR   OMA; VKTHVFH; -.
DR   Proteomes; UP000002624; Unassembled WGS sequence.
DR   GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR   GO; GO:0006000; P:fructose metabolic process; IEA:InterPro.
DR   CDD; cd07067; HP_PGM_like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR   InterPro; IPR003094; 6Pfruct_kin.
DR   InterPro; IPR013079; 6Phosfructo_kin.
DR   InterPro; IPR013078; His_Pase_superF_clade-1.
DR   InterPro; IPR029033; His_PPase_superfam.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10606; 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE; 1.
DR   PANTHER; PTHR10606:SF39; 6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED; 1.
DR   Pfam; PF01591; 6PF2K; 1.
DR   Pfam; PF00300; His_Phos_1; 1.
DR   PRINTS; PR00991; 6PFRUCTKNASE.
DR   SMART; SM00855; PGAM; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:EER40568.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002624};
KW   Transferase {ECO:0000313|EMBL:EER40568.1}.
FT   DOMAIN          45..237
FT                   /note="6-phosphofructo-2-kinase"
FT                   /evidence="ECO:0000259|Pfam:PF01591"
FT   REGION          486..534
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   534 AA;  59963 MW;  2DC351512D21FC2E CRC64;
     MDTLLTADVV AASPLFRKKS STYVDAIHDL PEKGELAPAQ LYSTESGRLF HSGRIVIITV
     GLPARGKTLG VKTRIFHLGD YRRATVGPGQ DVPDDYFFVN ASLVVSSAKI HENGQIAIYD
     AVNPIAAGRR SLAKEFAKHD IDTLFIESLC DDERIIEENV LSVKISSPDY VGWDPKDAVK
     DYLARISARI PQFQTMNEPE LNYIKMINAG ERMMINNRTF GYLHHRIVFY LLNLHIKSRH
     TYFVRAGTSR DPDSYKADAP LSEQGLDYAR KMTERLLQHR ESERQAQIIN QDGDDTDAEL
     KPLMVWTSTR RRTVETAQFL LKLGYKVRHR SQMSQLNPGV CEKMSERRIR MEYPDEVAKH
     ELDPYHHRYP RAESYHDLAV RLEPIILELE RERNDLLIIA HESVLRVLYG YLMACNAADI
     PFLSFPRDEI IEIIPASYNN KANRIHIPDL PPEIIPASPE GIKIPVPPSG VASPMPGWLD
     GCENRNSDVD GGGAEGSGLG TAGLGIPRGA TPSAGFRPSR DGEKILQHHA EDVV
//