ID C6HHB6_AJECH Unreviewed; 1198 AA.
AC C6HHB6;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=DEAD/DEAH box helicase {ECO:0000313|EMBL:EER40200.1};
GN ORFNames=HCDG_05597 {ECO:0000313|EMBL:EER40200.1};
OS Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544712 {ECO:0000313|EMBL:EER40200.1, ECO:0000313|Proteomes:UP000002624};
RN [1] {ECO:0000313|Proteomes:UP000002624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain H143.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG692427; EER40200.1; -; Genomic_DNA.
DR AlphaFoldDB; C6HHB6; -.
DR STRING; 544712.C6HHB6; -.
DR VEuPathDB; FungiDB:HCDG_05597; -.
DR eggNOG; KOG4150; Eukaryota.
DR HOGENOM; CLU_000809_1_0_1; -.
DR OMA; GAVHLHQ; -.
DR Proteomes; UP000002624; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17923; DEXHc_Hrq1-like; 1.
DR CDD; cd18797; SF2_C_Hrq; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR018973; MZB.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47957; ATP-DEPENDENT HELICASE HRQ1; 1.
DR PANTHER; PTHR47957:SF3; ATP-DEPENDENT HELICASE HRQ1; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF09369; MZB; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:EER40200.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002624}.
FT DOMAIN 400..583
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 623..776
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1198 AA; 133131 MW; F8EB27C89C89F4C1 CRC64;
MNNGLKRKAN ALNDGEHCAT EDGSGYLSRS PELPGEGQRG DVGRVYMSPS ARLPVEVATT
TTLPTKTHDG PSAAPLQPPK GKRGRRSASS SSRSSSTSSR GRPKKSPATS TPPIPWPEPF
KLLAQTHRAL NLVYTFCSAR KHFSTTFDNI KAAAEAQTGG RKLSVEDAAR VKVLIPRSVR
FESVDKGVVD LVGVNEAKGT GKIWRDLEIE GMGHDAEDSE GLNPDGGGDV LIFEFVDGDL
KKDPQRNSSR RRSKTDDIRV PVYSQKHMVT LIEKRNTKFS DAVDAFLAKC QDEDVDPVEK
LEADKDMYVP VLPRSGANTP AAMRLPAQIP KERATIAEII ASIREMEWYT DQIVPDGHRV
FDPQPAVYGD LTFALSQSLV NALYNTRGIT QFYSHQAEAI NNLHDGHNVI VSTSTSSGKS
LIYQVPMLHE LEQDPHSRGM YIFPTKALAQ DQRRSLKELL GYIEGLEHLL VETFDGDTPM
ADRNVIREEA RIIFTNPDML HITILPQESS WRTFLKNLKY VVVDELHVYN GLFGSHVAFI
MRRLRRICAA VGNRHVKFIS CSATVANPEE HMKTIFGIDD VRLTDIDGSP SGRKEFICWN
TPFRDPGDPS SGRGNSIQES SRLFCQLILR GVRVIAFCRI RKQCELLLAA VRDELKSLDR
INVSRFVMGY RGGYSPQDRR KIERDMFEGK LLGIVATNAL ELGVDIGSLD AVITHGFPYS
ISNLRQQSGR AGRRNKDSVS ILVGDSYATD QYYMRNPDEL FTKPNCELQV DLRNELVLEG
HVQCAAFEMP IKPDEDTEYF GPQLHEFAYT RLTKDSLGFY HCHERFRPHP SKCVAIRDTE
NNHYAIIDTT NNRNAVIEEI EESRVIFSIY EGGIFFHQGH PYMVKELNTD KRFARVIRVH
VDWTTQQRDI TDIDPIETEA IRRISSTANT KAFFGAIKIR AIVYGYFKLD KKGRILDAVA
LDNPPIEILS KGMWLDVPKQ ALDILKTRNL NAAAAIHAAE HAILSLMPTY IISSPGDVRT
ECKVAVKELG PKHQQAMNQT RSQNVKLPPV PARQRPARLT FYDAKGGSSG SGIAAKAFEF
VDSLLRRALG RIEACQCTSP QGCIECVCDE RCKEMNVVMS KAGAGVVLKC LLGIEVDVEA
LPWGEDVLGE RGVASDVVSI QEGKELAGGL ETIVEAMEVS ARPGARARIY GVEGVVEG
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