ID C6HIF6_AJECH Unreviewed; 762 AA.
AC C6HIF6;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Heat shock protein {ECO:0000313|EMBL:EER39618.1};
GN ORFNames=HCDG_05840 {ECO:0000313|EMBL:EER39618.1};
OS Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544712 {ECO:0000313|EMBL:EER39618.1, ECO:0000313|Proteomes:UP000002624};
RN [1] {ECO:0000313|Proteomes:UP000002624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain H143.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|ARBA:ARBA00008675, ECO:0000256|RuleBase:RU004432}.
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DR EMBL; GG692428; EER39618.1; -; Genomic_DNA.
DR AlphaFoldDB; C6HIF6; -.
DR STRING; 544712.C6HIF6; -.
DR VEuPathDB; FungiDB:HCDG_05840; -.
DR eggNOG; KOG1051; Eukaryota.
DR HOGENOM; CLU_005070_4_3_1; -.
DR OMA; SKMMQGE; -.
DR Proteomes; UP000002624; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF18; HEAT SHOCK PROTEIN 78, MITOCHONDRIAL; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 2.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|RuleBase:RU004432};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432};
KW Reference proteome {ECO:0000313|Proteomes:UP000002624};
KW Stress response {ECO:0000313|EMBL:EER39618.1}.
FT DOMAIN 123..267
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 526..680
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 665..756
FT /note="Clp ATPase C-terminal"
FT /evidence="ECO:0000259|SMART:SM01086"
FT COILED 336..416
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 762 AA; 84171 MW; 2152E8B0E9A0CD5C CRC64;
MQLFKLHGYS PRLLRASATG VRTPRPTQAS ISRTILCSQW PSSTRITYGP PYYRLPTIRH
YANGRPHPPG GTHRMNLGGE PEKPALEAYG VDLTARAKDG KLDPVIGRDG EIQRTIQILS
RRTKNNPVLI GSAGTGKTAI LEGLAQRIVR GDVPESVKDK RVIALDLGQL IAGAKFRGDF
EERLKKVLKE VEDAQGGVIL FVDELHTLLG LGKAEGSIDA SNLLKPALSR GELQCCGATT
LNEYRQIEKD VALARRFQPI LVEEPSVPDT ISILRGIKEK YEVHHGVRIT DGALVAAATY
SNRYITDRYL PDKAIDLVDE AASALRLQQE SKPDAIQELD RQIMTIQIEL ESLRKETDIT
SKERREKLEE LLKTKQNKVK ELTAVWEKEK AELDTIKQAK EDLERARVEL ELAQRQGNFA
KASELRYSII PGLESKLPKE GSETATTTTA DGEVLLHDSV TSDDIAAVVS RTTGIPVNKL
MAGEIEKLIN MEDTLRQSVR GQDEALSAVA NAVRMQRAGL SGENKPLASF MFLGPTGVGK
TELCKKMAGF LFSTETAVLR FDMSEFQEKH TVSRLIGSPA GYVGTSPSGP RRRLLTDAQG
HKIDFRNTLI VLTSNLGAEM LVAADSSVGE EISSDIKAAV MSIVQSSYPP EFLNRIDEFI
IFKRLSKPAL RDIVDIRLQE LQQRLDDRRI TLTVEDNVKD WLCDKGYDPR YGARPLNRLI
SKEIGNRLAD KIIRGEVVTG QGVSVIFNAD KSGLDIVSTK AT
//
