ID C6HIU9_AJECH Unreviewed; 1092 AA.
AC C6HIU9;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=histone acetyltransferase {ECO:0000256|ARBA:ARBA00013184};
DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
GN ORFNames=HCDG_05983 {ECO:0000313|EMBL:EER39761.1};
OS Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544712 {ECO:0000313|EMBL:EER39761.1, ECO:0000313|Proteomes:UP000002624};
RN [1] {ECO:0000313|Proteomes:UP000002624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain H143.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the MYST (SAS/MOZ) family.
CC {ECO:0000256|ARBA:ARBA00010107}.
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DR EMBL; GG692428; EER39761.1; -; Genomic_DNA.
DR AlphaFoldDB; C6HIU9; -.
DR STRING; 544712.C6HIU9; -.
DR VEuPathDB; FungiDB:HCDG_05983; -.
DR eggNOG; KOG2747; Eukaryota.
DR HOGENOM; CLU_005327_1_2_1; -.
DR OMA; DNAHRQC; -.
DR Proteomes; UP000002624; Unassembled WGS sequence.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 3.30.60.60; N-acetyl transferase-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR002717; HAT_MYST-type.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR040706; Zf-MYST.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10615; HISTONE ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR10615:SF102; HISTONE ACETYLTRANSFERASE; 1.
DR Pfam; PF01853; MOZ_SAS; 1.
DR Pfam; PF16866; PHD_4; 1.
DR Pfam; PF17772; zf-MYST; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51726; MYST_HAT; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002624};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 183..242
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 506..780
FT /note="MYST-type HAT"
FT /evidence="ECO:0000259|PROSITE:PS51726"
FT REGION 1..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 892..1002
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1019..1092
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..109
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..142
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..176
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..966
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 971..995
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1022..1041
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1061..1076
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 682
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR602717-51"
SQ SEQUENCE 1092 AA; 121166 MW; CD40CF76C8374E31 CRC64;
MAATVPATYG NTSIDRQPEL VDSDQDAEGD EDDELYPTLT QSATVIPQEN IDPPLTLGNG
DETIEASERE ENDGVGVGEV HEPETNHTDD VADMDEDEDA DADADADEDT EAIGAVKFPD
GNAKSDSDDE DDDIDDPDVE FENESSDVKA GSDGESSEES EVDEEWEAES NDGEDADADA
LNPNNCIVCG QDEEHDPSEE FEEYLSCAVC GDHCHRQCAR ERGTLNSEEA AENWRCPSCV
KNKLEPDKHE RTPSQRRSGT SNIAIDLLPA HSEALGPESH SIFSSLIVDD DPLDGSRSLR
KRRASDEGPE GNMVTQKRQK KIPARFEGMI PTPLPRNMKT VQALIEHSTE NNVTSRQSRP
RRTRKTEKAL CNIVQRQAGK IILSFHLNST KLNRILNSRQ KQISRRRPPK PPPVVESPQI
PFQPIAPSAY SAPFYAFHDR ENDELKSKPY GGILSEADAD TSRTLPLAAD REKFEAARQK
AEEEWRQKMA AADQPGESAP RAKISGPPSK IKYISFGGYE IETWYAAPYP EEYSRNRVLY
ICEFCLKYMN SDFVAWRHKL KCPAKHPPGD EIYRDGSVSV FEVDGRKNPV YCQNLCLLAK
LFLGSKTLYY DVEPFLFYVM TEYDELGCHF VGYFSKEKRP SSSNNVSCIL TLPIHQRKGY
GNLLIDFSYL LTRVERKTGS PEKPLSDLGL VSYRNYWRLV LSYQLRNQKS PVSIAELSER
TGMTADDIVS GLEGLRALVR DPQTKTYALR LNYAYFEEYI RNWEKKNYIR LNPNALVWTP
YVMGRSNQSH YDRAPLHTVA PRDEPDVDDD IEGNSDSNVY TNRAENMNGD TSSMQDGFVN
GHSHARSVSP PFDPPGPPSM SVMPFDGASL RQANGVRTPS VSSMMQNPAA GIPPTRFEIF
PPIPGTITKR RPGRPFGSTR ANKFRGRTTT TTAPTTARTS GRSTPKRTAS QVTGTPTPSS
RTIGLRRGRS SRFLDPNDAD EVMGDGIESR EGGELEQLES PTLQSTEVEA ANMEIRANAT
PESHAAASNN GRATGALENG NTNVDKAACA VPPSGDNKVN KHQATDLDHE RSQEAIQGPE
NHQSIDGIDE HT
//
