ID   C6HJT1_AJECH            Unreviewed;       835 AA.
AC   C6HJT1;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   SubName: Full=Hormone-sensitive lipase {ECO:0000313|EMBL:EER39357.1};
GN   ORFNames=HCDG_06462 {ECO:0000313|EMBL:EER39357.1};
OS   Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=544712 {ECO:0000313|EMBL:EER39357.1, ECO:0000313|Proteomes:UP000002624};
RN   [1] {ECO:0000313|Proteomes:UP000002624}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA   Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA   Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain H143.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG692429; EER39357.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6HJT1; -.
DR   STRING; 544712.C6HJT1; -.
DR   VEuPathDB; FungiDB:HCDG_06462; -.
DR   eggNOG; KOG4388; Eukaryota.
DR   HOGENOM; CLU_003590_1_0_1; -.
DR   OMA; NMYDATY; -.
DR   Proteomes; UP000002624; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013094; AB_hydrolase_3.
DR   PANTHER; PTHR23025:SF3; HORMONE-SENSITIVE LIPASE; 1.
DR   PANTHER; PTHR23025; TRIACYLGLYCEROL LIPASE; 1.
DR   Pfam; PF07859; Abhydrolase_3; 2.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   4: Predicted;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002624}.
FT   DOMAIN          181..332
FT                   /note="Alpha/beta hydrolase fold-3"
FT                   /evidence="ECO:0000259|Pfam:PF07859"
FT   DOMAIN          415..495
FT                   /note="Alpha/beta hydrolase fold-3"
FT                   /evidence="ECO:0000259|Pfam:PF07859"
FT   REGION          578..677
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          694..775
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        578..627
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        628..643
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        647..674
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        739..773
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   835 AA;  92355 MW;  176388F326860A50 CRC64;
     MIAVDRSCPG EAVDPVSQDT GLRRCVVLVL ISPTLTGLES PEPLANLYSR SYFRATWVTT
     ALDAGFWTAM NIKRKWLRDI ASIVFSIYYL IAAEHADEKV RKVRAVLTVE HLRVSWNKAT
     TPYLSFLGKL MRPRLMGYAP VQIRIPRPKE SSYRDPCIAW LYYNGPLSTL KNHTNIVLDI
     PGGGFVAMGP RMSDDKLLAW AARAGVPVLS LDYKKAPEYP YPYALNECYD VYHTIVSSRG
     RCIGLSGKVS PKIVITGDSA GGNLAVGVTL MVLQSGSTDS RKRRGENSLP PPVGLVLIYP
     SLDMNIGSWM TDEEMSLIRE RGMRETNCNV LRKKSEDYRK LASASSQVST LRDDSLEHPV
     IHDYFAQQHA GVIHEEHEPV IDTESIDKPV PGNTASQVVA TADKHPGQIE TRLAVSSMIS
     YFNDRILSPE MMRATIILYI GPYNRPDFSS DFLLSPLLAP EALLTRFPKT YFLTGERDPL
     VDDTVIFAGR IRQAKLRRFR ERQELGLERS MGTFDEKAHV EVSLIPGISH GFLQFPALFP
     EGWRQIFRCS RWIKKLFAHV AEGGTMVEGD LTASSIMSRR RQGNGSSETF RRVNSVSSTT
     LVMSGKPGTT RKGTGDNTGS QDHNRGLTGD SSGDEDRPLE MTRLNMSKRP PVSTGTSQSS
     LRSSPSSARS TADGSLLQPK AYMPTYLETS AGSLEPSSYL SLDPVALPDG GTGSDKTTPS
     PYPEPPNGAG RHKQPPRQNG DIAQPSPTFK FPQLSTSNGN RARSSSYNYN STHREKNDFA
     ENEDVVHSWR KHMTKMSRRR DESLTSLPSE EDLLGRRMNG LAGGLLGMGE GVRTP
//