ID   C6HT80_AJECH            Unreviewed;       334 AA.
AC   C6HT80;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Aldo/keto reductase {ECO:0000313|EMBL:EER36527.1};
GN   ORFNames=HCDG_09411 {ECO:0000313|EMBL:EER36527.1};
OS   Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=544712 {ECO:0000313|EMBL:EER36527.1, ECO:0000313|Proteomes:UP000002624};
RN   [1] {ECO:0000313|Proteomes:UP000002624}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA   Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA   Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain H143.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. Aldo/keto
CC       reductase 2 subfamily. {ECO:0000256|ARBA:ARBA00038157}.
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DR   EMBL; GG692440; EER36527.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6HT80; -.
DR   STRING; 544712.C6HT80; -.
DR   VEuPathDB; FungiDB:HCDG_09411; -.
DR   eggNOG; ENOG502QU2T; Eukaryota.
DR   HOGENOM; CLU_023205_1_1_1; -.
DR   OMA; APNYWHL; -.
DR   Proteomes; UP000002624; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd19075; AKR_AKR7A1-5; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43364:SF4; NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN; 1.
DR   PANTHER; PTHR43364; NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002624}.
FT   DOMAIN          12..304
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
SQ   SEQUENCE   334 AA;  37382 MW;  35346A85217D20F5 CRC64;
     MPLIVQNVKP RVILGLMTFG PDTEAGARVT SLDDYKKCLD YFQQQGYNEI DTARTYVDGK
     QEAFTAQAGW KERGLTIATK WYPKEPGHHH ASVVKEKLNQ SLKELQTDCV DIFYLHAADR
     SVPFAETLEA VNELHKEGKF VQLGLSNYAA FEVAEIVTMC NERARSIESE LIPACRRYGI
     DVVIYNPLAG GLLSGKYKTT EMPATGRFAN PSLGAMYRKR YFRDANLDAL RIIEPVVQKH
     NLTLVETALR WVHHHSALNI GTGPSSRDGI IIGVGSFEQL QANLADMEKG PLPKEVVDAL
     DEAWLIAKAT STDYWHMDLK YTYNTVEALF GPKA
//