ID   C6HUA9_9BACT            Unreviewed;       336 AA.
AC   C6HUA9;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=Isocitrate dehydrogenase (NAD(+)) {ECO:0000313|EMBL:EES53842.1};
GN   ORFNames=UBAL3_48660056 {ECO:0000313|EMBL:EES53842.1};
OS   Leptospirillum ferrodiazotrophum.
OC   Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC   Leptospirillum.
OX   NCBI_TaxID=412449 {ECO:0000313|EMBL:EES53842.1, ECO:0000313|Proteomes:UP000009374};
RN   [1] {ECO:0000313|EMBL:EES53842.1, ECO:0000313|Proteomes:UP000009374}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=19429552; DOI=10.1128/AEM.02943-08;
RA   Goltsman D.S., Denef V.J., Singer S.W., VerBerkmoes N.C., Lefsrud M.,
RA   Mueller R.S., Dick G.J., Sun C.L., Wheeler K.E., Zemla A., Baker B.J.,
RA   Hauser L., Land M., Shah M.B., Thelen M.P., Hettich R.L., Banfield J.F.;
RT   "Community genomic and proteomic analyses of chemoautotrophic iron-
RT   oxidizing "Leptospirillum rubarum" (Group II) and "Leptospirillum
RT   ferrodiazotrophum" (Group III) bacteria in acid mine drainage biofilms.";
RL   Appl. Environ. Microbiol. 75:4599-4615(2009).
CC   -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC       dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR   EMBL; GG693853; EES53842.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6HUA9; -.
DR   Proteomes; UP000009374; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR   PANTHER; PTHR11835:SF34; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR   Pfam; PF00180; Iso_dh; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR   PROSITE; PS00470; IDH_IMDH; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009374}.
FT   DOMAIN          5..329
FT                   /note="Isopropylmalate dehydrogenase-like"
FT                   /evidence="ECO:0000259|SMART:SM01329"
SQ   SEQUENCE   336 AA;  36605 MW;  F30AE3C17E455BB6 CRC64;
     MGKHVITMLP GEGTGPEICE AARRVIDHSG VEIVWEYEDI GLDCLDKYGT LLPEKTIKSI
     AKNKIAIKGP TTTPVGTGHK SANVTLRKLF DLYANVRPAK LIPVLKRPWD QIDILTFREN
     TEDSYAAIEH MVSDEVAQCL KVITWPGSVR IAEFAFKWAK ANGRKKIQCV HKANIMKMTD
     GLFLEAFREV AKKYPEIEAG DIIVDNCCMQ LVRNPAQFDC LVLPNLYGDI LSDLCAGLVG
     GLGFAPGANI GDNCSIFEAV HGSAPKYAGM KKVNPSAVLL SGVMMLRWIG ENAAADKIEK
     GMNKVLAEAK TLTYDAGGTA STDEYADAII RAMDTV
//