ID C6KT09_PLAF7 Unreviewed; 521 AA.
AC C6KT09;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Malate:quinone oxidoreductase {ECO:0000313|EMBL:CAG25406.1};
DE EC=1.1.5.4 {ECO:0000313|EMBL:CAG25406.1};
GN ORFNames=PF3D7_0616800 {ECO:0000313|EMBL:CAG25406.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAG25406.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000313|EMBL:CAG25406.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C., Harris B., Harris D.,
RA Mungall K., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corto C., Cronin A., Davies R.,
RA Davies P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James D.,
RA Johnson D., Kerhornou A., Knight A., Kontfortov B., Keyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., McLean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M-A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC {ECO:0000256|ARBA:ARBA00005163}.
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DR EMBL; AL844505; CAG25406.1; -; Genomic_DNA.
DR RefSeq; XP_966154.1; XM_961061.1.
DR AlphaFoldDB; C6KT09; -.
DR SMR; C6KT09; -.
DR STRING; 36329.C6KT09; -.
DR PaxDb; 5833-PFF0815w; -.
DR EnsemblProtists; CAG25406; CAG25406; PF3D7_0616800.
DR GeneID; 3885985; -.
DR KEGG; pfa:PF3D7_0616800; -.
DR VEuPathDB; PlasmoDB:PF3D7_0616800; -.
DR HOGENOM; CLU_613842_0_0_1; -.
DR InParanoid; C6KT09; -.
DR OMA; NFLFEVP; -.
DR OrthoDB; 198325at2759; -.
DR PhylomeDB; C6KT09; -.
DR UniPathway; UPA00223; -.
DR Proteomes; UP000001450; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0047545; F:2-hydroxyglutarate dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; ISS:GeneDB.
DR GO; GO:0006090; P:pyruvate metabolic process; ISS:GeneDB.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR PANTHER; PTHR43104; L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43104:SF2; L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:CAG25406.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450}.
SQ SEQUENCE 521 AA; 59507 MW; 173004DE24EC9D41 CRC64;
MICVKNILKR YKNSPLNELR NNRKYYEGSF VKSIKFSTSN YGSNEKKPND IEKNKNVSIN
LNEGNILQSE IYDTVVIGGG VTGTALFFLL SKFTNLKKLA IIERRDNFAL VASHGKNNSQ
TIHCGDIETN YSFEKAKFIK RYADMLRNYL TNIPKEKREN ISSVTQKMVL GVGEKECQFL
EERYPVFRQL FNSMKLYNKD DIHEVEPRVA LKDSHTLREE QLSALYMPPE LTTCDYQKLS
ESFIESARTV PNKTISINLL TEVINIEEVN DSLYKIHTNK GIINSRFVVV CACGHSLMIA
QKMNYGLEYS CMPVAGSFYF TDNILKGKVY TIQNPALPFA AVHGDPDIIE KGKTRFGPTA
IPLPLLERDN IKTLLDFLKV WNPDLSLFQV YYNLFKDMTM LKYVARNVLF EIPVLNKYLF
LKDVKKIIPS LTIKDLTYCV GYGGVRPQLI NKKSKKLILG EGKIDPGKNI IFNITPSPGA
TTCLGNGEFD MNTICERLNA KINKNDVKKY LYEGEYPVNY L
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