ID   C6KWJ4_9BACT            Unreviewed;       493 AA.
AC   C6KWJ4;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   SubName: Full=2-hydroxymuconic semialdehyde dehydrogenase {ECO:0000313|EMBL:BAH90341.1};
OS   uncultured bacterium.
OC   Bacteria; environmental samples.
OX   NCBI_TaxID=77133 {ECO:0000313|EMBL:BAH90341.1};
RN   [1] {ECO:0000313|EMBL:BAH90341.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Suenaga H., Ohnuki T., Miyazaki K.;
RT   "Functional screening of a metagenomic library for genes involved in
RT   microbial degradation of aromatic compounds.";
RL   Environ. Microbiol. 9:2289-2297(2007).
RN   [2] {ECO:0000313|EMBL:BAH90341.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Suenaga H., Koyama Y., Miyakoshi M., Miyazaki R., Yano H., Sota M.,
RA   Ohtsubo Y., Tsuda M., Miyazaki K.;
RT   "Novel organization of aromatic degradation pathway genes in a microbial
RT   community as revealed by metagenomic analysis.";
RL   ISME J. 0:0-0(2009).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003345}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB266148; BAH90341.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6KWJ4; -.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd07093; ALDH_F8_HMSADH; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR017628; OHmuconic_semiald_DH.
DR   NCBIfam; TIGR03216; OH_muco_semi_DH; 1.
DR   PANTHER; PTHR43720; 2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43720:SF2; 2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003345}.
FT   DOMAIN          22..489
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
FT   ACT_SITE        261
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   493 AA;  52784 MW;  EFAED5B097311411 CRC64;
     MKDGQLGAHD ALHFINGEYT AGSTGKTFEN ISPATGARIG LVHEGGKAEI DAAVAAAKAA
     LTGPWGYMSQ AERADMLHAV ADEINRRFDD FLDAEVLDTG KPRSLAKHVD IPRGAANFKI
     FADLVKNVPT ESFMLDTPDG KGALNYGVRK PKGVIAVISP WNLPLLLMTW KVGPALASGN
     TVVVKPSEET PLTATLLGEV MNAVGVPKGV FNVVHGFGPD SAGAYLTAHP EVDGITFTGE
     TRTGEIIMQS AAIGLRHVSM ECGGKNAAIV FADADIEKAV EGTMRSVFAN CGQVCLGTER
     VYVERPLFDT FLARLKDEAE NMVLGASDDP NTTMGPLISQ EHREKVMSYF KLAVEEGANV
     ITGGGIPEMP EDLSGGAWVQ PTIFTGLSED ARCVKEEIFG PVCHVAPFDT EEEAIKLAND
     TRYGLATAIW TEDLTRAHRV ARQIDVGLAW VNSWFLRDLR TAFGGSKHSG IGREGGIHGL
     EFYSELSNVC VKL
//