ID C6LNS6_GIAIB Unreviewed; 561 AA.
AC C6LNS6;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Protein 21.1 {ECO:0000313|EMBL:EET02342.1};
GN ORFNames=GL50581_382 {ECO:0000313|EMBL:EET02342.1};
OS Giardia intestinalis (strain ATCC 50581 / GS clone H7) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=598745 {ECO:0000313|EMBL:EET02342.1, ECO:0000313|Proteomes:UP000002488};
RN [1] {ECO:0000313|EMBL:EET02342.1, ECO:0000313|Proteomes:UP000002488}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50581 / GS clone H7 {ECO:0000313|Proteomes:UP000002488};
RX PubMed=19696920; DOI=10.1371/journal.ppat.1000560;
RA Franzen O., Jerlstrom-Hultqvist J., Castro E., Sherwood E., Ankarklev J.,
RA Reiner D.S., Palm D., Andersson J.O., Andersson B., Svard S.G.;
RT "Draft genome sequencing of giardia intestinalis assemblage B isolate GS:
RT is human giardiasis caused by two different species?";
RL PLoS Pathog. 5:E1000560-E1000560(2009).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EET02342.1}.
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DR EMBL; ACGJ01000532; EET02342.1; -; Genomic_DNA.
DR AlphaFoldDB; C6LNS6; -.
DR EnsemblProtists; EET02342; EET02342; GL50581_382.
DR VEuPathDB; GiardiaDB:GL50581_382; -.
DR OMA; GHHALIM; -.
DR OrthoDB; 5475587at2759; -.
DR Proteomes; UP000002488; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR24120:SF4; ANKYRIN REPEAT AND SOCS BOX PROTEIN 12; 1.
DR PANTHER; PTHR24120; GH07239P; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00248; ANK; 12.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT REPEAT 191..213
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 222..245
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 512..548
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 561 AA; 61307 MW; 767212D8679DED59 CRC64;
MSILDKFTWF NVCRAGLTNQ IKDNISKFKT TRDEVTGATA LMHACVDNNL EVVRILLPYE
DVVTDNSGKT GLMIAAEHGY LDLAKLLMVT QVGKQRENGQ TALMHAAAYD FEEVVELLLP
REGTMIDRNG WTALMCAVWR GSNKAASILA QVEAGMTSYQ GETAFLCACD AGNYELAKLL
LEKEGKSTLR SGETGLHLAA RSGSKAIVEL LLETLCRKQT QAGKTALMYA ASAGNLEIVL
LLLEREVGYQ DAEGRTATMG AILNGHEDCM KVLLPREKDI VDKKGRSALE IAQSTAPSVM
SYHVAALLGG TVDPTTGSTT LIQATRLGLF DIIKILIPAQ TNLTDESGMC AIHYAVASHN
LECTKLLKPY EGKALNANGH HALIMAVMEG NVSVILELIE HSWLPDAEGN YPITYCAENP
MGDIYQLLFS HMIQTHPNFK VVIRSFCDAL HKGFSLLANE YSDSENLEFL SELLLLISEL
FFSPEKLAAS QITADITALL DSFTVAVHES PCCVCIDRPA FVIIRPCLHM CICSTCVASL
RGRCPYCQST VAEYFEIALE E
//
