ID C6LSL0_GIAIB Unreviewed; 464 AA.
AC C6LSL0;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Protein 21.1 {ECO:0000313|EMBL:EET00993.1};
GN ORFNames=GL50581_1749 {ECO:0000313|EMBL:EET00993.1};
OS Giardia intestinalis (strain ATCC 50581 / GS clone H7) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=598745 {ECO:0000313|EMBL:EET00993.1, ECO:0000313|Proteomes:UP000002488};
RN [1] {ECO:0000313|EMBL:EET00993.1, ECO:0000313|Proteomes:UP000002488}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50581 / GS clone H7 {ECO:0000313|Proteomes:UP000002488};
RX PubMed=19696920; DOI=10.1371/journal.ppat.1000560;
RA Franzen O., Jerlstrom-Hultqvist J., Castro E., Sherwood E., Ankarklev J.,
RA Reiner D.S., Palm D., Andersson J.O., Andersson B., Svard S.G.;
RT "Draft genome sequencing of giardia intestinalis assemblage B isolate GS:
RT is human giardiasis caused by two different species?";
RL PLoS Pathog. 5:E1000560-E1000560(2009).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EET00993.1}.
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DR EMBL; ACGJ01002197; EET00993.1; -; Genomic_DNA.
DR AlphaFoldDB; C6LSL0; -.
DR EnsemblProtists; EET00993; EET00993; GL50581_1749.
DR VEuPathDB; GiardiaDB:GL50581_1749; -.
DR OMA; AGMQDQD; -.
DR OrthoDB; 66380at2759; -.
DR Proteomes; UP000002488; Unassembled WGS sequence.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR24120:SF4; ANKYRIN REPEAT AND SOCS BOX PROTEIN 12; 1.
DR PANTHER; PTHR24120; GH07239P; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00248; ANK; 7.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT DOMAIN 410..448
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 464 AA; 51501 MW; 14B6C3E6AA5C3DF2 CRC64;
METHRDATAR GPSSTGSKIG KSTALMQAVK ERHIEAVYSL AERECGCLDE KGDTALILAA
SSGNYDAVFI LAPLEAGVRG PGRQTALMHL SSLGCPPQLL KQLIHAEARL TDDRGWTALM
FAALWGHIEV VSHLADLEAG MQDQDGMTAL MYATSKKRLD VVEYLLIHHA RKEAGRQNNL
GRTALMIAAT LNGAESCMIV QKLVAKEAKI KDRDGLTALM LAARCDNESN IDTLIHLSHL
EAKMQDSSGR TALIHACLHG SGTALEVLAR NEVGLLDKHG CCALNYCIED YKVTFYPYLV
SELDIISRRN PYKQLFSRRT LLIDLVFLSS HYKIASILRR WLHAIVVKLG DTINFDMSIK
SNVLDLSIYT FIELLFNYYV DCEPITISDL LHSYDALLDV ALETHLHTMC SICLDFPASV
IYRPCRHMVV CTQCYKRSEQ LRSKCVICMS SVSDAVVVSL FECK
//
