ID   C6LSP2_GIAIB            Unreviewed;       411 AA.
AC   C6LSP2;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=Protein 21.1 {ECO:0000313|EMBL:EET00981.1};
GN   ORFNames=GL50581_1782 {ECO:0000313|EMBL:EET00981.1};
OS   Giardia intestinalis (strain ATCC 50581 / GS clone H7) (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=598745 {ECO:0000313|EMBL:EET00981.1, ECO:0000313|Proteomes:UP000002488};
RN   [1] {ECO:0000313|EMBL:EET00981.1, ECO:0000313|Proteomes:UP000002488}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50581 / GS clone H7 {ECO:0000313|Proteomes:UP000002488};
RX   PubMed=19696920; DOI=10.1371/journal.ppat.1000560;
RA   Franzen O., Jerlstrom-Hultqvist J., Castro E., Sherwood E., Ankarklev J.,
RA   Reiner D.S., Palm D., Andersson J.O., Andersson B., Svard S.G.;
RT   "Draft genome sequencing of giardia intestinalis assemblage B isolate GS:
RT   is human giardiasis caused by two different species?";
RL   PLoS Pathog. 5:E1000560-E1000560(2009).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EET00981.1}.
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DR   EMBL; ACGJ01002198; EET00981.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6LSP2; -.
DR   EnsemblProtists; EET00981; EET00981; GL50581_1782.
DR   VEuPathDB; GiardiaDB:GL50581_1782; -.
DR   OMA; ICALLNH; -.
DR   OrthoDB; 5475903at2759; -.
DR   Proteomes; UP000002488; Unassembled WGS sequence.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR24184:SF11; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR24184; SI:CH211-189E2.2; 1.
DR   Pfam; PF12796; Ank_2; 2.
DR   SMART; SM00248; ANK; 6.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REPEAT          268..290
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..37
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..52
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   411 AA;  44783 MW;  8AAD20C6FE8C9969 CRC64;
     MAPRPQHPLA RVNSQTDPPV SRKDAVKSRR GAPPRKACPK EPQKPPPPIP LDQIDEDGNT
     GLHRAVLQEQ HIYISDASKH AGCRNKAQKT ALHLAAEKGD FTAIGHLIML PGEVGVRVGT
     SVKCGRYIMW KPTALMICAL LNHNTQLVVN GDEEPKLHEA LRELVKVESG KQDWSGYTAL
     MYACIAGNTP LATELVSFEA GIQSKGGWSA LMLATQLGQL SIAAKLYRRE YGLQNAGGWT
     ALMDAAVNGR LEIAHLLAPK EQGMRTKKGK TALMLAVCNG HIDIATLLLK EAGHEDSFGY
     SALMYAVQMS HLPLVQLLGP MEGECYAERA LGLLKDTTTP EVRTRYQEAM IGNEQNPLES
     DICEVLLNEN DTPQHSQPLS LLSDCNDPEF LPGELKCPIT PSELSTELGD K
//