ID C6LT06_GIAIB Unreviewed; 744 AA.
AC C6LT06;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Kinase, NEK {ECO:0000313|EMBL:EET00853.1};
GN ORFNames=GL50581_1899 {ECO:0000313|EMBL:EET00853.1};
OS Giardia intestinalis (strain ATCC 50581 / GS clone H7) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=598745 {ECO:0000313|EMBL:EET00853.1, ECO:0000313|Proteomes:UP000002488};
RN [1] {ECO:0000313|EMBL:EET00853.1, ECO:0000313|Proteomes:UP000002488}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50581 / GS clone H7 {ECO:0000313|Proteomes:UP000002488};
RX PubMed=19696920; DOI=10.1371/journal.ppat.1000560;
RA Franzen O., Jerlstrom-Hultqvist J., Castro E., Sherwood E., Ankarklev J.,
RA Reiner D.S., Palm D., Andersson J.O., Andersson B., Svard S.G.;
RT "Draft genome sequencing of giardia intestinalis assemblage B isolate GS:
RT is human giardiasis caused by two different species?";
RL PLoS Pathog. 5:E1000560-E1000560(2009).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EET00853.1}.
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DR EMBL; ACGJ01002222; EET00853.1; -; Genomic_DNA.
DR AlphaFoldDB; C6LT06; -.
DR EnsemblProtists; EET00853; EET00853; GL50581_1899.
DR VEuPathDB; GiardiaDB:GL50581_1899; -.
DR OMA; TECANEL; -.
DR OrthoDB; 5477021at2759; -.
DR Proteomes; UP000002488; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 4.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR24120:SF4; ANKYRIN REPEAT AND SOCS BOX PROTEIN 12; 1.
DR PANTHER; PTHR24120; GH07239P; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00248; ANK; 11.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Kinase {ECO:0000313|EMBL:EET00853.1};
KW Transferase {ECO:0000313|EMBL:EET00853.1}.
FT DOMAIN 1..269
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 447..479
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
SQ SEQUENCE 744 AA; 83154 MW; BE1B3AB0A1ED833E CRC64;
MQSTDDKKES SYTIISEGKP LCTAVNDLNG RVCFCERISL KRFKHKHKEK INMYLNKISL
LNHVNLVKYS PHRNSISNLF SDVYTDMNYG CTLQDMIDEH IFYQEPFSEE QIWDILVQCL
AGLSYIHNWK DLDGNSSLPH GCLDPQFIYF DSFGVLKIGN FAKSCINAAS AIAAQQPQMY
DAPEVKTTGT RSHVSDTYSL AKLIHGLATI DHHFCSDPTV SVAELRKLYP FPEISLQYSN
ELYNIIKLMA TAEEERRPSA TALLKNPLIA DHVSDLNARR GIVLGVNNRT ELMNAVLRGD
VDAVLSLLPY QVGLVERSGK TALIHAAESG HVEIAKHLVR YECRYQIVAN GEWRGMTALM
FAARNGNHGI VTILKPYECN ISTESGHFAL RLATVSGRTE CANELFIDEF RLLRHFGWTT
LMIGTVFTFT ELNKNFLSTD LGQQDNRGFT ALMVAAANNK NDMLDYLIER EAGMSNCNDY
TALMAAARAN NVQAVNMLIP REAGMKDDNG WSALMYAAHG NNIECILALL DKEAGLQSNG
LQTAMMIAAQ CNHLEAVKML APYEQKKQDI DGFTAFLYAS DRGNCQIVDF LLDFEGEMVS
NSGYTGLMLA AKKGHAKIVK LLAKSLSKRV TNMFNRAPGT TALMFACFNR QYECAKILCR
YERGMKTTVG TTALMAAVSS KAPDCVQLLA PHELFMKNID NKTVFDMDTT EEIREILLLQ
KVKRNVAKQT LLGDSEEKQP EDVN
//
