ID C6LTE9_GIAIB Unreviewed; 1023 AA.
AC C6LTE9;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=N-acetyltransferase-like protein {ECO:0000313|EMBL:EET00702.1};
GN ORFNames=GL50581_2046 {ECO:0000313|EMBL:EET00702.1};
OS Giardia intestinalis (strain ATCC 50581 / GS clone H7) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=598745 {ECO:0000313|EMBL:EET00702.1, ECO:0000313|Proteomes:UP000002488};
RN [1] {ECO:0000313|EMBL:EET00702.1, ECO:0000313|Proteomes:UP000002488}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50581 / GS clone H7 {ECO:0000313|Proteomes:UP000002488};
RX PubMed=19696920; DOI=10.1371/journal.ppat.1000560;
RA Franzen O., Jerlstrom-Hultqvist J., Castro E., Sherwood E., Ankarklev J.,
RA Reiner D.S., Palm D., Andersson J.O., Andersson B., Svard S.G.;
RT "Draft genome sequencing of giardia intestinalis assemblage B isolate GS:
RT is human giardiasis caused by two different species?";
RL PLoS Pathog. 5:E1000560-E1000560(2009).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EET00702.1}.
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DR EMBL; ACGJ01002263; EET00702.1; -; Genomic_DNA.
DR AlphaFoldDB; C6LTE9; -.
DR EnsemblProtists; EET00702; EET00702; GL50581_2046.
DR VEuPathDB; GiardiaDB:GL50581_2046; -.
DR OMA; CGDSNNC; -.
DR OrthoDB; 1119820at2759; -.
DR Proteomes; UP000002488; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008080; F:N-acetyltransferase activity; IEA:InterPro.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.11040; -; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000182; GNAT_dom.
DR InterPro; IPR007807; Helicase_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032672; TmcA/NAT10/Kre33.
DR InterPro; IPR013562; TmcA_N.
DR InterPro; IPR027992; tRNA_bind_dom.
DR PANTHER; PTHR10925; N-ACETYLTRANSFERASE 10; 1.
DR PANTHER; PTHR10925:SF5; RNA CYTIDINE ACETYLTRANSFERASE; 1.
DR Pfam; PF13718; GNAT_acetyltr_2; 1.
DR Pfam; PF05127; Helicase_RecD; 1.
DR Pfam; PF08351; TmcA_N; 1.
DR Pfam; PF13725; tRNA_bind_2; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EET00702.1};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 19..216
FT /note="tRNA(Met) cytidine acetyltransferase TmcA N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08351"
FT DOMAIN 380..583
FT /note="Helicase"
FT /evidence="ECO:0000259|Pfam:PF05127"
FT DOMAIN 632..859
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13718"
FT DOMAIN 863..1007
FT /note="Possible tRNA binding"
FT /evidence="ECO:0000259|Pfam:PF13725"
FT REGION 301..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1023 AA; 114947 MW; 0DEBBCEE0AD9CB0B CRC64;
MAQSIRVNNR GESLKAIDKR LTTLLSSGYE SFQRSLIIIV GDGGLYQVPN LFNILKMTRT
SQISIMWCYD EMPKLSSNTR KRNKAFRHLK NRGELQEEEL SVEAQFYANT NIRYLHYRDT
ELALGTTVDM LILQDFKALT PNIIGQTVEC VRGGGLILFL LNNMHDLSQL HAVVMNFHSR
FSNINNREVT NELRIKARFN SRFIALLDYL PRFLLVNDTL EVIQITEGIQ NLMTNLSVQD
GSAEKRTAAF TAYKNEHKSS SLLTKTFISL CATLEQAKLV VQVLEMLDNV DKIRRMNSKN
SILEKEATKH NNKGPREPSR KRYFVREKET YIREDTAESS VDQDADASLE EQNAGHELLQ
TLTQNANTLA SATRFPICSL IAARGRGKSA SLGLIVALMI FQGYNHVLIS APNPVNVQTV
FEFCIIGLKA LDYQEARDYT VRRAGLKATD PIIELRVTRK VKQVIAYIVP STLAAYCQAN
EKASNSILSF IDAILLDECA TIPLKLVRQI VDSVEANMLC FISSTCYGYE ASGRALSLKL
LHDLEKSGSK RGQELVKLSL NEPIRYAPND TVEKWVNQLL CLDQVNGLVT SLEEGPEVAA
SFPQPQSCTL YRINKDALFS GLPQSELFLQ AIWSIFSASH YKNSPNDLIL LSDNPLHELF
VLCPPITDSK RIPTVLCACQ ICYEGKLKQN IVKEALSQQK RLDGDMIAWL LSQQFQDVSF
SSLSGARVVR IATNASYMRG GYGSHTLELL SSFFKGELLN PTEVKRLETK KKERVEKLAK
QKGISIDDAK QEIESLTPAL LQNCGTVYPS DLTWLGVGFG ITIDLLNFWR KNHYLPVYVR
QTRNDTTGEH TCLMIRSLKD NPFISSFASS FRSRFLRLLR YDFAELPIEI AFKVSWPTNT
VALTHDADQA AIMTLLTKQD VIRLRGFVRH QLDFMAVRDL VPILAELIFT EKLSPVSLSH
ASARIFLGIG LMNMRQVDVA QQLGLVSDVA FSQVESIFTK TVEVLLRILE PLFGLGAGAG
ISK
//
