ID C6LWT3_GIAIB Unreviewed; 1358 AA.
AC C6LWT3;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=Helicase {ECO:0000313|EMBL:EES99502.1};
GN ORFNames=GL50581_3245 {ECO:0000313|EMBL:EES99502.1};
OS Giardia intestinalis (strain ATCC 50581 / GS clone H7) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=598745 {ECO:0000313|EMBL:EES99502.1, ECO:0000313|Proteomes:UP000002488};
RN [1] {ECO:0000313|EMBL:EES99502.1, ECO:0000313|Proteomes:UP000002488}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50581 / GS clone H7 {ECO:0000313|Proteomes:UP000002488};
RX PubMed=19696920; DOI=10.1371/journal.ppat.1000560;
RA Franzen O., Jerlstrom-Hultqvist J., Castro E., Sherwood E., Ankarklev J.,
RA Reiner D.S., Palm D., Andersson J.O., Andersson B., Svard S.G.;
RT "Draft genome sequencing of giardia intestinalis assemblage B isolate GS:
RT is human giardiasis caused by two different species?";
RL PLoS Pathog. 5:E1000560-E1000560(2009).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EES99502.1}.
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DR EMBL; ACGJ01002726; EES99502.1; -; Genomic_DNA.
DR EnsemblProtists; EES99502; EES99502; GL50581_3245.
DR VEuPathDB; GiardiaDB:GL50581_3245; -.
DR OMA; ADECDNI; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000002488; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EES99502.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 109..268
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 424..593
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 812..827
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..846
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1358 AA; 151350 MW; 0BB28BCDEBC3358B CRC64;
MIALQDRDGN DTPEERFGVT TGVSNGLSQL QTVLMDQGLL EQTKKLPVVV DVSEPATEDP
LKKIHHSVVF PYGYDIPKDP ADKIYTCEPP AELPVKFPYE LDPFQRRAIG ALHIGHSVLV
AAHTSAGKTT VAEYIIATAL AQNQRVVYTT PIKALSNQKY QDLKLAAYTK GSVGIMTGDT
TLNRTAGVLV MTTEILRNML HQGAELLREI GYVIFDEVHY MRNSERGLVW EDCIAMLSSN
IQFCFLSATV PNASEFAGWV ASLHSIPVHV VYTQYRPVPL MHFLCPVGGD GIYPICSSID
KNKIRHDQVI KAKANLPHDN AQAVARGEEE GTSGHSNKKQ QQKAIRDTLH RVMKNLIARD
CFPLIVFAFG KKKCEAYAMD FIGDYFSGGQ RVATSQSPSQ RTHGEEPQTL APHNDQPSTQ
TQPPIVQSLV TPEQTRIIDN IFDAALKCLP EEDRNLRPVV VLRGMLRRGI AVHHSGLLPW
AKEIIEILFV EGLVKILYAT ETFAMGLNLP ARAIIFSEFK KFDGLTSRLV TAGEYVQMAG
RAGRRGIDKQ GMSICMFSTA DECDNIVKVI QGTTEPLNSA YRLSFNSVLK LMQIEDSSPE
QVIKRSFLQF QQLFRLPRCL NKILSLEDAN TMDKAQLFAL LLNIFSILQR LSKENEQLAQ
FFGQDMLHSL EMLAVGDIQR LYDLLTEYIN LFALRASYYA DRSRLLSQDS MKQLLIHGRI
VHVHADGLDM GWVPVLKVIR SGADSFVDCL VPCSLGSVPA KYTNASESHL IAFSDTVPSS
LSSQGVDKEL ACAVLVNKSY YQTYTSMLQR QDGTDVAEDT PTSENQPPVK KRPLRKVGSK
PDQRQKVSHA DINDLIYAND CSESITPQTL YEYSFIDPLQ PFVRENKASY QMLAPRDILL
SVLTAINKCE ASSKKKQMRG KLHEHLWAEL ASTACVIVRI PVRAIRGVSG KILKNLPENM
YRYDDKSEAM FLYYQMIASL IPSDDSHNFS STLADLMEPH INLSELAYSD VTSEVNELEC
NIKLVEHAIA CDTEYGILTR IFSCPAYHMP VLHRVLNAIG SPAIYAKIST QNEDANGQTL
EEKQLDIYKM VKEYLAGSQD EGASGQMEIS GMVFSLILNC MRRDAKKQIF KQYIQEADEL
ILSSELIKLK NFLHREHFIE EIPGAADGEA AYLLTDKGRV ACHVSSANEV ILVECLFEAQ
FTDLTPRVLA GVLASLLGEG TGASKSSQLQ MDPKLSQALS KLKQIVSNLL KDCAIEDTTL
ELRCTTVDHI VDDTAAVIAF SWAAGQTFQE ILDIDRSQFE GSIVRMFRRL INLVDQLVIA
VEVIGDDRLK ARLTAVHDAI FRDIIKVNSL YVVAEDDV
//
