ID   C6LXS1_GIAIB            Unreviewed;      1071 AA.
AC   C6LXS1;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   RecName: Full=PX domain-containing protein {ECO:0000259|PROSITE:PS50195};
GN   ORFNames=GL50581_3587 {ECO:0000313|EMBL:EES99204.1};
OS   Giardia intestinalis (strain ATCC 50581 / GS clone H7) (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=598745 {ECO:0000313|EMBL:EES99204.1, ECO:0000313|Proteomes:UP000002488};
RN   [1] {ECO:0000313|EMBL:EES99204.1, ECO:0000313|Proteomes:UP000002488}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50581 / GS clone H7 {ECO:0000313|Proteomes:UP000002488};
RX   PubMed=19696920; DOI=10.1371/journal.ppat.1000560;
RA   Franzen O., Jerlstrom-Hultqvist J., Castro E., Sherwood E., Ankarklev J.,
RA   Reiner D.S., Palm D., Andersson J.O., Andersson B., Svard S.G.;
RT   "Draft genome sequencing of giardia intestinalis assemblage B isolate GS:
RT   is human giardiasis caused by two different species?";
RL   PLoS Pathog. 5:E1000560-E1000560(2009).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EES99204.1}.
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DR   EMBL; ACGJ01002895; EES99204.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6LXS1; -.
DR   EnsemblProtists; EES99204; EES99204; GL50581_3587.
DR   VEuPathDB; GiardiaDB:GL50581_3587; -.
DR   OMA; FPTKQIE; -.
DR   OrthoDB; 5483190at2759; -.
DR   Proteomes; UP000002488; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   CDD; cd06093; PX_domain; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   Pfam; PF00787; PX; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   PROSITE; PS50195; PX; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}.
FT   DOMAIN          959..1071
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          67..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          517..537
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          630..791
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          544..585
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        517..533
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        654..729
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        737..756
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        757..775
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        776..791
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1071 AA;  119745 MW;  165F7B51FE63428E CRC64;
     MDSDQGQGGY EGYGWGDYGT SQDDTATDRQ SPYAMAEDTG YYGAPYAADG DSNPYAYAYG
     FPESNAYNEP QGVYGDVPSL GNEPPTNEEP PGYQLADTCE SEVSRLEDPE DDVQPQEVGE
     LTNDPNPSES LQNEMFGFGD NLADGASEAA ATTEPDNAFG FFGFDDAPST SAAISEANAA
     DLAAFSDATP VITFSDYTIS SAPISVSRLA TPSDSVFADV DAPVALSLEP ETASSAHAED
     SAALLEHLRR VRKMLVIDQI LRLRAAVGAD RVFRDIQPQQ LASVESREEI SVAVPQDESL
     QQLLSEEPQS SQEVVPLHSF SNIGECASDE ATPKLQADPD TERSIREAEA IIEEALMHTP
     EVKDLESLPD MATAPLSDAP ETLEDIIATE QHPECLSNKV ESDSFERIQD SELIDELKSE
     MSQWGQQPLE EHSHADSICR QATPNDSMPN EIISTDLYDQ EDQEDQDQAA YFDALVVDRI
     ATPDTLDDIL GPPESLDACQ EDLHVERQET FEEHVYKSED KDTLQVTEGE QRASGDEELD
     DFDIEMARRE AEMLEQARRE EEEMLRQAEE DLYRQEEEQQ EVVEEVDHVV QEELSIIARL
     DSPAISAASL SDGLCVDRLD SPAAEVYSVT EHVSKPCDKH KAEHPKHGLT KEKHHAVKQK
     EEKQKEEKTE KHEKQKPERA EKADKAPKHE VDKAKTSTIK KKPKPVEQAK EAVVEKPREV
     AKEETPTKPH SAAKSATETS HIDKKPAKKQ QKSKKAPVEQ ELSTTVSSVA ESSQDEDIIS
     AKKARDEARL QEKLRKQQEQ LQALEEQKRH QEEEELQRIL AEEKLRMDKE IERATRKADR
     EYQKLEMEKK RFAISSQIES RSATASGIET SGSLLSDKEL MRELRLRERR DKELQALRHN
     IEASTEKESD SADYDPSLQT LSAVRRHSYG ATSSLVGRTK HKDGGRHVSS FVDTSSYSNF
     YVKVLSHRTV IISGTRPFIS YYIEFGMDGR KLRISCRFSE VKELHAAISA AYPATTLPNL
     PPDRPYALGG WKPEFIKERT KLLEAYLYSM HSITFVRTSN IYRQFLKAAR C
//