ID   C6LYD3_GIAIB            Unreviewed;      1389 AA.
AC   C6LYD3;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   RecName: Full=Leucine-rich repeat protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=GL50581_3806 {ECO:0000313|EMBL:EES98975.1};
OS   Giardia intestinalis (strain ATCC 50581 / GS clone H7) (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=598745 {ECO:0000313|EMBL:EES98975.1, ECO:0000313|Proteomes:UP000002488};
RN   [1] {ECO:0000313|EMBL:EES98975.1, ECO:0000313|Proteomes:UP000002488}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50581 / GS clone H7 {ECO:0000313|Proteomes:UP000002488};
RX   PubMed=19696920; DOI=10.1371/journal.ppat.1000560;
RA   Franzen O., Jerlstrom-Hultqvist J., Castro E., Sherwood E., Ankarklev J.,
RA   Reiner D.S., Palm D., Andersson J.O., Andersson B., Svard S.G.;
RT   "Draft genome sequencing of giardia intestinalis assemblage B isolate GS:
RT   is human giardiasis caused by two different species?";
RL   PLoS Pathog. 5:E1000560-E1000560(2009).
CC   -!- SIMILARITY: Belongs to the ANP32 family.
CC       {ECO:0000256|ARBA:ARBA00025777}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EES98975.1}.
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DR   EMBL; ACGJ01002910; EES98975.1; -; Genomic_DNA.
DR   EnsemblProtists; EES98975; EES98975; GL50581_3806.
DR   VEuPathDB; GiardiaDB:GL50581_3806; -.
DR   OMA; RICAYMN; -.
DR   OrthoDB; 5361311at2759; -.
DR   Proteomes; UP000002488; Unassembled WGS sequence.
DR   Gene3D; 1.20.5.340; -; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR045081; AN32.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR11375; ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32; 1.
DR   PANTHER; PTHR11375:SF0; ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A; 1.
DR   Pfam; PF00560; LRR_1; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS51450; LRR; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          238..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1331..1355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          337..378
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          615..659
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1119..1188
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        238..267
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1389 AA;  154465 MW;  62943DB497DB3503 CRC64;
     MSSPMVRAAL TDAPNKEGDG GKVMLDISER NLETLANLGS LISPQTKSLN ISNNKLSSLN
     DLLPMFQLLN FNASYNMIVQ IDQVLPFPKL QTLNLSHNRI VRLTCAIPLS LRTLDLSHNN
     IYSIDLIAPV LSLKALESLD IRGNPLMEQK AYQDIISNFP QLGTFNGRAV QDFYPQSGEK
     AELTLSELTD RHSHNAASTH KPKPKLVIDE QVILFSRSGA PTSQIARHRV AAHSLTSNLA
     SEQAGKSTLP SPTSAAPPQS VDRATTPNYH PTYADAEFQT DMSYKDMRRR TMYDFSDEDD
     DAAISISDTP DANEAKRLKR VKALLKNSEQ IVDSTYIHTL QGQLQSYKQN EERLRGEVDA
     LEQQLEKLRA SNALLQSAVR PVETISSTER QNFMLSSQID EVIFLREQVK ILDELLNRQE
     AASAVQFPVP EAIPEYLSTL NAYRRKLFHV MFDLRQLKYT KENVDVSCLI APALDDTHGP
     LHKLEADLIS IAEEKDQLSA KHDEVLNKLT VSEHAARAFH DEATKYLSIL LRIQTGLKAD
     PRTSKLDGLD EHMSKRICAY MNTSKAPTLD DAQKYILAAS ESASYRLAAQ CSVLETVIDR
     INDILSENQV IKEEKIQLCQ ELAVLTQERN ELKEDNLLLK GTLRQQREEK ARLEELRASG
     YLDKAILCTE IDLGEIVHGS TQTYLDEFFN HIEIQADPQE FLVSKSVQFV RELFNVDDET
     QTGNLRELTN YNNSQFDTLP ASTPASVEHV EDDADDEDYQ RLLQLKDIHD RSKGTDCTII
     PSSILLKLHI DTAGEDTPES VLDAAIRSLL STQPSTLIKE NMFGGESAKL DGNERIHTGI
     QVETPLPVFK AVQCELLQTI NGTGDSIVPR YKSYSEGHES ELSSVEDATT TVVFAAIQVD
     APDMKYFGTQ TDEVDVAPYG TLAALQLRMS NSEEKLTVVL DTKVASTQCE EIAIVFRSVQ
     CPEPELHDTP KNDSLVSDAS DAYSTALSDP KNLTLGQNMC AETSVQTDES LTYLQQKPHI
     SNVPLDEVLI RVTPIPDTAA SRDMQTCPFC NKEFLVSGST PIKEEIDLPN ERNSPCISRM
     YSPPPSPYLR EMEYECCCNT AAEQLHKQAQ VLAARELELE DMNEVVSEVM KTISSAENKV
     SSYKKKLQDS QDTISNLQDA IAQLQGDLTS AEAKGTEHEA RVRDLEKLLH VEDGEEHLDA
     EIQTRLNLVD MKLLFAQMRV ATSSTSTQYE SQLTVLRDHN EVLDSSVVVH NLSSEDIKRS
     LVSKNCSASK MVSKSEELRA SLFEPAVIPL TPPLSTPSSS DGEGSLETSF RSSPFVSLKI
     ETAGSGCGRD GTTVSVFHPS NNALKRPKQP PEKSSVRVQI AKLPHEESET RVRFFCAPDS
     YGARPVIIH
//