ID   C6LZG4_GIAIB            Unreviewed;       538 AA.
AC   C6LZG4;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 58.
DE   SubName: Full=Ubiquitin-activating enzyme E1 1 {ECO:0000313|EMBL:EES98565.1};
GN   ORFNames=GL50581_4195 {ECO:0000313|EMBL:EES98565.1};
OS   Giardia intestinalis (strain ATCC 50581 / GS clone H7) (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=598745 {ECO:0000313|EMBL:EES98565.1, ECO:0000313|Proteomes:UP000002488};
RN   [1] {ECO:0000313|EMBL:EES98565.1, ECO:0000313|Proteomes:UP000002488}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50581 / GS clone H7 {ECO:0000313|Proteomes:UP000002488};
RX   PubMed=19696920; DOI=10.1371/journal.ppat.1000560;
RA   Franzen O., Jerlstrom-Hultqvist J., Castro E., Sherwood E., Ankarklev J.,
RA   Reiner D.S., Palm D., Andersson J.O., Andersson B., Svard S.G.;
RT   "Draft genome sequencing of giardia intestinalis assemblage B isolate GS:
RT   is human giardiasis caused by two different species?";
RL   PLoS Pathog. 5:E1000560-E1000560(2009).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EES98565.1}.
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DR   EMBL; ACGJ01002923; EES98565.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6LZG4; -.
DR   EnsemblProtists; EES98565; EES98565; GL50581_4195.
DR   VEuPathDB; GiardiaDB:GL50581_4195; -.
DR   OMA; RFDIKQM; -.
DR   OrthoDB; 20494at2759; -.
DR   UniPathway; UPA00885; -.
DR   Proteomes; UP000002488; Unassembled WGS sequence.
DR   GO; GO:0019781; F:NEDD8 activating enzyme activity; IEA:UniProtKB-EC.
DR   GO; GO:0045116; P:protein neddylation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR045886; ThiF/MoeB/HesA.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   PANTHER; PTHR10953:SF102; ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3; 1.
DR   PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
PE   4: Predicted;
FT   DOMAIN          3..404
FT                   /note="THIF-type NAD/FAD binding fold"
FT                   /evidence="ECO:0000259|Pfam:PF00899"
SQ   SEQUENCE   538 AA;  59660 MW;  2FC205481FCFD392 CRC64;
     MNLCIVGCGG IGCEVAKLVA CSPARYASVA VIDMDTVELS NINRQFLYSR DDVGREKSHA
     TADYLREKAP TVKVISYSET IINPKRFGPR FFSQYDVIVT CLDAFAPRRY VGEMCWLSNR
     LLVDAGTSGL SGSVTGYPPT SYWRADDPTM ECYNCYNRDV RIEIPICTMK NKPTRPEHCV
     SYSILLAQRM YDVDPYSELI EYAPININGS IDEVLSDLVR FLYYSFNTHL SDNPSASTVL
     TLEEIEQAKQ RVSCLFGAPE SGDGLTQPCL KHTLSPLTYT LHEHMSTEQT LKEVLVSAVL
     LARSIASNEY VFTTYDRNNP HLVTLVSGLA LLRMHSFGIT TALTLFELST LAGSIVPAVT
     FTNAAVAALA MKLAHMIFSS FLAKQHHKEN VLLQHFIKNS RRSLLISDDL RPSNPECAVC
     GIPYYILTVK DSSFLSIDTI IECLSKELSA TISVIYGGDV LIYEDDVPSG WTDNSSTPES
     GEKAETAKDT LQSIAQIYDG ELLKIIYSSH DQGRLSVRVM VQIDSSMKEA YVFTVGRA
//