ID   C6M0D8_GIAIB            Unreviewed;       524 AA.
AC   C6M0D8;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   24-JAN-2024, entry version 44.
DE   SubName: Full=Topoisomerase I-related protein {ECO:0000313|EMBL:EES98263.1};
GN   ORFNames=GL50581_4526 {ECO:0000313|EMBL:EES98263.1};
OS   Giardia intestinalis (strain ATCC 50581 / GS clone H7) (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=598745 {ECO:0000313|EMBL:EES98263.1, ECO:0000313|Proteomes:UP000002488};
RN   [1] {ECO:0000313|EMBL:EES98263.1, ECO:0000313|Proteomes:UP000002488}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50581 / GS clone H7 {ECO:0000313|Proteomes:UP000002488};
RX   PubMed=19696920; DOI=10.1371/journal.ppat.1000560;
RA   Franzen O., Jerlstrom-Hultqvist J., Castro E., Sherwood E., Ankarklev J.,
RA   Reiner D.S., Palm D., Andersson J.O., Andersson B., Svard S.G.;
RT   "Draft genome sequencing of giardia intestinalis assemblage B isolate GS:
RT   is human giardiasis caused by two different species?";
RL   PLoS Pathog. 5:E1000560-E1000560(2009).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EES98263.1}.
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DR   EMBL; ACGJ01002930; EES98263.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6M0D8; -.
DR   EnsemblProtists; EES98263; EES98263; GL50581_4526.
DR   VEuPathDB; GiardiaDB:GL50581_4526; -.
DR   OMA; REKCKEW; -.
DR   OrthoDB; 21395at2759; -.
DR   Proteomes; UP000002488; Unassembled WGS sequence.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:1990817; F:poly(A) RNA polymerase activity; IEA:InterPro.
DR   CDD; cd05402; NT_PAP_TUTase; 1.
DR   Gene3D; 1.10.1410.10; -; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR   InterPro; IPR045862; Trf4-like.
DR   PANTHER; PTHR23092:SF15; INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED; 1.
DR   PANTHER; PTHR23092; POLY(A) RNA POLYMERASE; 1.
DR   Pfam; PF01909; NTP_transf_2; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR   SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
PE   4: Predicted;
KW   Isomerase {ECO:0000313|EMBL:EES98263.1}.
FT   DOMAIN          129..232
FT                   /note="Polymerase nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF01909"
FT   REGION          40..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          301..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..56
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..319
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   524 AA;  58650 MW;  0BD60EC95175516E CRC64;
     MNDLLKVINE AREKAPEERA AANIEFEDII FEASEFTEPG LKRQHTQQED LRSLPRSQKK
     PTPSIAKLKD GVDGVDVPWL PQEQLLKLAN LPYLTRLNLE ILQYVAYCTL TEAERAAREY
     VLGQLTDVIQ LVLPDAIVDV FGSYSTGMSS YSSDLDICVN VPVSDAATLH RHMYNIASLL
     RSSISTNYVD VRSHARVPII KGVHSELSLE YDISFNSPHG AAHRESILNY IEKHPLARVL
     IMVVKSFLKK RGLNQPYTGG MSSYILLQLI VVYISERHNV FPYCITGENL ALLESGEADP
     DQPAISSMDE SNSNLLTKPR RPSTHKKEQV QASIESELLT NRFHAASLIE FFELFGTIYN
     AEDLTIYTNP RGNESFVSPR RTSSHYHQSI KGGSSPFLSV LNSHDPTSDC AGGVTRYKYI
     RSSFELAYFY LLRNNPGSIL SFLVEVDFTS MHTREKCKEW YDTRSSTAAQ DWAAKIEALG
     VMQTSLTPSS YNIRSLAMGG VDFEEDLGED VIDVSTSSSS HSPE
//