ID C6M0D9_GIAIB Unreviewed; 650 AA.
AC C6M0D9;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Kinase, NEK {ECO:0000313|EMBL:EES98264.1};
GN ORFNames=GL50581_4527 {ECO:0000313|EMBL:EES98264.1};
OS Giardia intestinalis (strain ATCC 50581 / GS clone H7) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=598745 {ECO:0000313|EMBL:EES98264.1, ECO:0000313|Proteomes:UP000002488};
RN [1] {ECO:0000313|EMBL:EES98264.1, ECO:0000313|Proteomes:UP000002488}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50581 / GS clone H7 {ECO:0000313|Proteomes:UP000002488};
RX PubMed=19696920; DOI=10.1371/journal.ppat.1000560;
RA Franzen O., Jerlstrom-Hultqvist J., Castro E., Sherwood E., Ankarklev J.,
RA Reiner D.S., Palm D., Andersson J.O., Andersson B., Svard S.G.;
RT "Draft genome sequencing of giardia intestinalis assemblage B isolate GS:
RT is human giardiasis caused by two different species?";
RL PLoS Pathog. 5:E1000560-E1000560(2009).
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. NEK Ser/Thr
CC protein kinase family. NIMA subfamily. {ECO:0000256|ARBA:ARBA00010886}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EES98264.1}.
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DR EMBL; ACGJ01002930; EES98264.1; -; Genomic_DNA.
DR EnsemblProtists; EES98264; EES98264; GL50581_4527.
DR VEuPathDB; GiardiaDB:GL50581_4527; -.
DR OMA; IEQPRIN; -.
DR OrthoDB; 5474480at2759; -.
DR Proteomes; UP000002488; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR43671:SF13; LD04361P; 1.
DR PANTHER; PTHR43671; SERINE/THREONINE-PROTEIN KINASE NEK; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:EES98264.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Transferase {ECO:0000313|EMBL:EES98264.1}.
FT DOMAIN 10..276
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 564..596
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 281..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 650 AA; 71368 MW; 4FDDA5177FDA2CD0 CRC64;
MGGETFEDQF EPIELLGSGS FGKVHKVRSR KDGRIYACKE IEYTKMSSKE VSLLQSEVIN
LRRMSHPHII AYYSTIHDQD ASVVFIINEY CGKGDLTKYI RTYRQKKENI PEATIWNMFH
QMALALEYCH SPNKPGFKPG EIVIHRDIKP ANVLITDDDQ LKLADFGFCR TIGLDTMAQT
KAGSPVYCAP EVLREEDYNE KADIWSLGCV IYELCCVEYA YSSINEKFLL ISMMQQKRKP
IPSCYSRDLA EVIERMLQVD FKKRPSATEL LAHPKFKEYN LTRGSSKSPA PAAARNPAPS
GKHSATGNTP SQSPQPGAAA ARNAASLGRV STSPERPVPA AAGQYGSNLT APPSRGAVAA
TPTVPVNANK GASKDSGQLH DVIVRQKKEI DELKARVSSG STAHGISENA RNTIVKASDE
IKKKDDEIIR LSDTVFSKEE ENAALRREIA AYEXFTTTVL MPRPGENPLA DGVTRLMLAA
QKGLTAVVQH LLSQEIGLRS ASGKTALMYA AENGQNACVR LLMDKEGGMQ DNKGTTALMR
ASIGGRFETC KILFARESGM QSQEGDTALT YATIRGNTEI IRLLAPREAG LQLKDGKTAL
MSAASRGFLE AVKILYDKEG KLVDKNGRDA LYYAQQKNLG DIVAFLQSKK
//