ID C6S4R6_NEIML Unreviewed; 495 AA.
AC C6S4R6;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=ATP-dependent helicase {ECO:0000313|EMBL:CBA03608.1};
GN Name=hrpA {ECO:0000313|EMBL:CBA03608.1};
GN OrderedLocusNames=NMO_0159 {ECO:0000313|EMBL:CBA03608.1};
OS Neisseria meningitidis (strain alpha14).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=662598 {ECO:0000313|EMBL:CBA03608.1, ECO:0000313|Proteomes:UP000002054};
RN [1] {ECO:0000313|EMBL:CBA03608.1, ECO:0000313|Proteomes:UP000002054}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=alpha14 {ECO:0000313|Proteomes:UP000002054};
RX PubMed=18305155; DOI=10.1073/pnas.0800151105;
RA Schoen C., Blom J., Claus H., Schramm-Glueck A., Brandt P., Mueller T.,
RA Goesmann A., Joseph B., Konietzny S., Kurzai O., Schmitt C., Friedrich T.,
RA Linke B., Vogel U., Frosch M.;
RT "Whole-genome comparison of disease and carriage strains provides insights
RT into virulence evolution in Neisseria meningitidis.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:3473-3478(2008).
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DR EMBL; AM889136; CBA03608.1; -; Genomic_DNA.
DR AlphaFoldDB; C6S4R6; -.
DR KEGG; nmi:NMO_0159; -.
DR HOGENOM; CLU_001832_5_7_4; -.
DR Proteomes; UP000002054; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR CDD; cd17989; DEXHc_HrpA; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.10.10.2130; DEAH helicase family, winged-helix domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR042035; DEAH_win-hel_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010222; RNA_helicase_HrpA.
DR NCBIfam; TIGR01967; DEAH_box_HrpA; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:CBA03608.1};
KW Hydrolase {ECO:0000313|EMBL:CBA03608.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 101..264
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 288..461
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 495 AA; 55053 MW; 59D591D4F83CA1BC CRC64;
MRFSDGISPS RYCPNPTKAF AIILFFTAYA PIMFPDFSQT LSKDRHFLQS AFKNPNKYGG
LSKVEEKYRK SHEIFLKRLA ALPKPEFDNT LPVHEKLDEI KKTVAEHQVT IICGETGSGK
TTQLPKICLE LGRGAAGLIG HTQPRRLAAR SVAERIAEEL KSEIGSAVGY KVRFTDHTSR
DACVKLMTDG ILLAETQTDR YLAAYDTIII DEAHERSLNI DFLLGYLKQL LPRRPDLKVI
ITSATIDTEG FSRHFNGAPV LEVSGRTYPV EILYSPLTGK DEDDAEVELT DAIVDAADEL
AQYGEGDILV FLPGEREIRE AAEALRKSTL RRNDEILPLF ARLSHAEQHK IFHPSGAKRR
IVLATNVAET SLTVPGIKYV IDTGLARVKR YSARAKVEQL HIEKISQAAA HQRSGRCGRV
SAGVCIRLFS EENFNNRPEF TDPEIARSNL AAVILRMASL KLGDVAAFPF LEMPDSRYIN
DGFQVLLELG AVEAA
//
