GenomeNet

Database: UniProt
Entry: C6SN35_NEIME
LinkDB: C6SN35_NEIME
Original site: C6SN35_NEIME 
ID   C6SN35_NEIME            Unreviewed;       766 AA.
AC   C6SN35;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   24-JAN-2024, entry version 63.
DE   RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN   Name=recQ {ECO:0000313|EMBL:CBA09921.1};
GN   ORFNames=NMW_2367 {ECO:0000313|EMBL:CBA09921.1};
OS   Neisseria meningitidis alpha275.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=295996 {ECO:0000313|EMBL:CBA09921.1};
RN   [1] {ECO:0000313|EMBL:CBA09921.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Alpha275 {ECO:0000313|EMBL:CBA09921.1};
RX   PubMed=18305155; DOI=10.1073/pnas.0800151105;
RA   Schoen C., Blom J., Claus H., Schramm-Glueck A., Brandt P., Mueller T.,
RA   Goesmann A., Joseph B., Konietzny S., Kurzai O., Schmitt C., Friedrich T.,
RA   Linke B., Vogel U., Frosch M.;
RT   "Whole-genome comparison of disease and carriage strains provides insights
RT   into virulence evolution in Neisseria meningitidis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:3473-3478(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001665};
CC   -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC       {ECO:0000256|ARBA:ARBA00005446}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM889138; CBA09921.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6SN35; -.
DR   GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   GO; GO:0009432; P:SOS response; IEA:InterPro.
DR   CDD; cd17920; DEXHc_RecQ; 1.
DR   CDD; cd18794; SF2_C_RecQ; 1.
DR   Gene3D; 1.10.150.80; HRDC domain; 3.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR   InterPro; IPR006293; DNA_helicase_ATP-dep_RecQ_bac.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR044876; HRDC_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR032284; RecQ_Zn-bd.
DR   InterPro; IPR018982; RQC_domain.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   NCBIfam; TIGR01389; recQ; 1.
DR   NCBIfam; TIGR00614; recQ_fam; 1.
DR   PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR   PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF00570; HRDC; 3.
DR   Pfam; PF16124; RecQ_Zn_bind; 1.
DR   Pfam; PF09382; RQC; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00341; HRDC; 3.
DR   SMART; SM00956; RQC; 1.
DR   SUPFAM; SSF47819; HRDC-like; 3.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50967; HRDC; 3.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:CBA09921.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CBA09921.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          27..195
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          216..366
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   DOMAIN          524..604
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
FT   DOMAIN          610..690
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
FT   DOMAIN          691..766
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
SQ   SEQUENCE   766 AA;  85927 MW;  3E095240AB6D51C6 CRC64;
     MHRPTAKQIL HEVFGYPEFR GRQEAVINTL AGGGSLTVLM PTGGGKSLCY QIPALMREGV
     AVVVSPLIAL MNDQVANLHA AGIEAAAVNS GTSADEAREI ADRLAQGRLK LLYVAPERLV
     TDRFLRFLDQ QTVSLFAIDE AHCVSQWGHD FRPEYQQLGM LAERYPNVPR IALTATADAA
     TRADIKHYLH LDDAPEFISS FDRPNIYYQV IEKNNGKKQL LEFIRKEMAG QSGIVYCLSR
     KKVEDVAQFL RENGLNAIPY HAGLSMDVRE ENQRRFTHED NIIVVATVAF GMGIDKPDVR
     FVAHLDMPQS VEHFYQESGR AGRDGLPAAS WLCYGLNDWV LLRERIAEGN SDEVQKQIEM
     QKLDAMLSVC ETAACRRVLL LKHFGEESEP CGHCDNCLHP PVRFDGTVLV QKLLSCVYRA
     GQRFAAGYIT NLLRGKSDDW IRGNRHEQLS TFGIGAELSD KEWRSVIRQC ISLGYLTVNI
     ARYQALQLTE AAKKVLKGET EVMLRPLKRG KPAARTLKDN WLRTEREERL WQALRVWRMK
     QAEAEGIPAY MIFGDKTLRD LVEKMPQNLN GLHDIYGLGE AKTERFGHGI LEVCRNAAGF
     SRDAVIRPQT EREQQLRQKL EAWRYEQARA ENCALHAVLS DESLADMLAD TPETETDLEG
     VHGLGSVRAA KYGRDILAVC RPFSDGIDET AKHKRRLMRA LIQWCNETAK HEQSEPYRIL
     SKAALRAIAA KQPEGLAELA AVYGVGEEKA ARYGAAVLAV LERNAV
//
DBGET integrated database retrieval system