ID C6SN35_NEIME Unreviewed; 766 AA.
AC C6SN35;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=recQ {ECO:0000313|EMBL:CBA09921.1};
GN ORFNames=NMW_2367 {ECO:0000313|EMBL:CBA09921.1};
OS Neisseria meningitidis alpha275.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=295996 {ECO:0000313|EMBL:CBA09921.1};
RN [1] {ECO:0000313|EMBL:CBA09921.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Alpha275 {ECO:0000313|EMBL:CBA09921.1};
RX PubMed=18305155; DOI=10.1073/pnas.0800151105;
RA Schoen C., Blom J., Claus H., Schramm-Glueck A., Brandt P., Mueller T.,
RA Goesmann A., Joseph B., Konietzny S., Kurzai O., Schmitt C., Friedrich T.,
RA Linke B., Vogel U., Frosch M.;
RT "Whole-genome comparison of disease and carriage strains provides insights
RT into virulence evolution in Neisseria meningitidis.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:3473-3478(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; AM889138; CBA09921.1; -; Genomic_DNA.
DR AlphaFoldDB; C6SN35; -.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR006293; DNA_helicase_ATP-dep_RecQ_bac.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR01389; recQ; 1.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 3.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 3.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 3.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:CBA09921.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:CBA09921.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 27..195
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 216..366
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 524..604
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT DOMAIN 610..690
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT DOMAIN 691..766
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
SQ SEQUENCE 766 AA; 85927 MW; 3E095240AB6D51C6 CRC64;
MHRPTAKQIL HEVFGYPEFR GRQEAVINTL AGGGSLTVLM PTGGGKSLCY QIPALMREGV
AVVVSPLIAL MNDQVANLHA AGIEAAAVNS GTSADEAREI ADRLAQGRLK LLYVAPERLV
TDRFLRFLDQ QTVSLFAIDE AHCVSQWGHD FRPEYQQLGM LAERYPNVPR IALTATADAA
TRADIKHYLH LDDAPEFISS FDRPNIYYQV IEKNNGKKQL LEFIRKEMAG QSGIVYCLSR
KKVEDVAQFL RENGLNAIPY HAGLSMDVRE ENQRRFTHED NIIVVATVAF GMGIDKPDVR
FVAHLDMPQS VEHFYQESGR AGRDGLPAAS WLCYGLNDWV LLRERIAEGN SDEVQKQIEM
QKLDAMLSVC ETAACRRVLL LKHFGEESEP CGHCDNCLHP PVRFDGTVLV QKLLSCVYRA
GQRFAAGYIT NLLRGKSDDW IRGNRHEQLS TFGIGAELSD KEWRSVIRQC ISLGYLTVNI
ARYQALQLTE AAKKVLKGET EVMLRPLKRG KPAARTLKDN WLRTEREERL WQALRVWRMK
QAEAEGIPAY MIFGDKTLRD LVEKMPQNLN GLHDIYGLGE AKTERFGHGI LEVCRNAAGF
SRDAVIRPQT EREQQLRQKL EAWRYEQARA ENCALHAVLS DESLADMLAD TPETETDLEG
VHGLGSVRAA KYGRDILAVC RPFSDGIDET AKHKRRLMRA LIQWCNETAK HEQSEPYRIL
SKAALRAIAA KQPEGLAELA AVYGVGEEKA ARYGAAVLAV LERNAV
//