ID C6TP59_DROME Unreviewed; 743 AA.
AC C6TP59;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=FI03665p {ECO:0000313|EMBL:ACU32629.1};
DE Flags: Fragment;
GN Name=Mer-RA {ECO:0000313|EMBL:ACU32629.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ACU32629.1};
RN [1] {ECO:0000313|EMBL:ACU32629.1}
RP NUCLEOTIDE SEQUENCE.
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000256|ARBA:ARBA00004536}. Cell projection, rhabdomere
CC {ECO:0000256|ARBA:ARBA00043944}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; BT099545; ACU32629.1; -; mRNA.
DR AlphaFoldDB; C6TP59; -.
DR EnsemblMetazoa; FBtr0074754; FBpp0074523; FBgn0086384.
DR VEuPathDB; VectorBase:FBgn0086384; -.
DR HOGENOM; CLU_003623_6_1_1; -.
DR Bgee; FBgn0086384; Expressed in egg cell and 25 other cell types or tissues.
DR ExpressionAtlas; C6TP59; baseline and differential.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13194; FERM_C_ERM; 1.
DR CDD; cd17097; FERM_F1_ERM_like; 1.
DR Gene3D; 1.20.5.450; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 6.10.360.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR011174; ERM.
DR InterPro; IPR011259; ERM_C_dom.
DR InterPro; IPR041789; ERM_FERM_C.
DR InterPro; IPR046810; ERM_helical.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR008954; Moesin_tail_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23281; MERLIN/MOESIN/EZRIN/RADIXIN; 1.
DR PANTHER; PTHR23281:SF39; MOESIN_EZRIN_RADIXIN HOMOLOG 2; 1.
DR Pfam; PF00769; ERM_C; 1.
DR Pfam; PF20492; ERM_helical; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF48678; Moesin tail domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 2: Evidence at transcript level;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136}.
FT DOMAIN 120..413
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 33..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 420..559
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACU32629.1"
SQ SEQUENCE 743 AA; 86130 MW; EF7BF2950EF59FC5 CRC64;
VQLRFAVQTI DHQPKLPLPL PGAPNWLQNE AVRDRRGPQE QQQGIVPLDG TGAPEGPRIR
LAGATSPLHA TGYHELPTRA LSSHSNPIAS NASHHIASNL IKTHHIIAMS PFGSKKNRSL
SVRVSTFDSE LEFKLEPRAS GQDLFDLVCR TIGLRESWYF GLQYVDTRSN VSWLKMEKRV
RDQRVELHAS NNVYVFSFYA KFFPENVSEE LIQEITQHLF FLQVKQSILS MDIYCRPEAS
VLLASYAVHV QYGPYDYETY KDGMLAGGEL LPKGVTDQYQ MTPEMWEERI KTWYMDHEPM
TRDEVEMEYL KIAQDLDMYG VNYFPITNKN KTKLWLGVTS VGLNIYDERD KLTPKTTFQW
NEIRHVSFDD KKFTIRLVDA KVSNFIFYSQ DLHINKMILD LCKGNHDLYM RRRKPDTMEI
QQMKAQAKEE KQRRQIERKK FIREKKLREK AEHERYELEK SMEHLQNEMR MANDALRRSE
ETKELYFEKS RVNEEQMQLT ECKANHFKTE MDRLRERQMK IEREKHDLEK KIRDADFYVH
QLTVENDKRE AETEKLRKEL ICAKMAEREA TARLLEFLNS GRKSSTDSLL TASSVSHAAN
TASSMAAIST PSLITSSSTN DLETAGGAEL TTHSSHYLVQ GDNSSGISDD FEPKEFILTD
NEMEQITNEM ERNHLDYLRN SKQVQSQLQT LRSEIAPHKI EENQSNLDIL SEAQIKAGEN
KYSTLKKLKS GSTKARVAFF EEL
//
