ID C6V4M1_NEORI Unreviewed; 745 AA.
AC C6V4M1;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN Name=cckA {ECO:0000313|EMBL:ACT69348.1};
GN OrderedLocusNames=NRI_0351 {ECO:0000313|EMBL:ACT69348.1};
OS Neorickettsia risticii (strain Illinois).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Anaplasmataceae; Neorickettsia.
OX NCBI_TaxID=434131 {ECO:0000313|EMBL:ACT69348.1, ECO:0000313|Proteomes:UP000001627};
RN [1] {ECO:0000313|EMBL:ACT69348.1, ECO:0000313|Proteomes:UP000001627}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Illinois {ECO:0000313|EMBL:ACT69348.1,
RC ECO:0000313|Proteomes:UP000001627};
RX PubMed=19661282; DOI=10.1093/nar/gkp642;
RA Lin M., Zhang C., Gibson K., Rikihisa Y.;
RT "Analysis of complete genome sequence of Neorickettsia risticii: causative
RT agent of Potomac horse fever.";
RL Nucleic Acids Res. 37:6076-6091(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP001431; ACT69348.1; -; Genomic_DNA.
DR RefSeq; WP_015816237.1; NC_013009.1.
DR AlphaFoldDB; C6V4M1; -.
DR STRING; 434131.NRI_0351; -.
DR KEGG; nri:NRI_0351; -.
DR eggNOG; COG0745; Bacteria.
DR eggNOG; COG4191; Bacteria.
DR HOGENOM; CLU_000445_114_51_5; -.
DR OrthoDB; 9796100at2; -.
DR Proteomes; UP000001627; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43065:SF10; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3; 1.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF13188; PAS_8; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:ACT69348.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Transferase {ECO:0000313|EMBL:ACT69348.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 58..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 371..599
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 623..738
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 674
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 745 AA; 84909 MW; 08F52A420F5DF72D CRC64;
MKSRYTDGIK KNKLNFVIRY PRRFFLVFIL MLLQFLCGAP IVLEFNSIDL LGVYEIKGLF
YAFGIIIFFL LTYNLKKLHL VLAAAEFQNM FYSNAAKALT EFYLIITNNG EVVYRDERTK
VKNLQSLLGE KYEKFISDIR EGVLYHRFSC DGQVIEIIPM IRPKGYFIVA ARRVGEREIY
DVLLREAGVS LYSVKGDSLQ YRGARYFEEV SYKKTFLEDE LYRLTEVFLT EQNRKGLFLQ
NYRRCLNDTH YGVLVPKLKE IRELADNASI GIVLMSNDLE IISANDAFFD IFEKGDQIKQ
FLRDKLSDLK RGDGPSIFNF STESGDSARL YLSNYGILNA GFLVDLSELS DLQKKFQHSQ
KIVSLGELSG GIAHDFNNIL TAIMGFAEIL LEDVRLESKH YYNIAQIRYS AKKGRDLVKK
ILAFSRKQTL HPEVLSMAEV VKSMRQFVER LVPENIKLTF VIRSGLKNVR VDRTEIEQSL
INLIVNARDA IEACGEITVE IAETFVNKKY VVLIGTQNEE VVLKGEYISL TVRDNGCGMN
KEILSKIFDP FFSTKSVDKG TGLGLSTVYG IMKQMKGYIN VESTEGQGSV FTLLIPVSYE
DISNDAKKVD EDLVPSEKSK GAKILLVEDE KIVRNFLVKA LTRQGFSVVE YESSKSALEK
FEEEKDTAVL LITDVVMPGM DGPEMVKEMR KQKADLKVLF MSGYTRDKLH LDSKNRDEIF
IAKPFGINEL ISKVISLTED RGQSA
//
