ID C6W5I0_DYAFD Unreviewed; 864 AA.
AC C6W5I0;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN OrderedLocusNames=Dfer_2983 {ECO:0000313|EMBL:ACT94198.1};
OS Dyadobacter fermentans (strain ATCC 700827 / DSM 18053 / CIP 107007 / KCTC
OS 52180 / NS114).
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Spirosomataceae;
OC Dyadobacter.
OX NCBI_TaxID=471854 {ECO:0000313|EMBL:ACT94198.1, ECO:0000313|Proteomes:UP000002011};
RN [1] {ECO:0000313|EMBL:ACT94198.1, ECO:0000313|Proteomes:UP000002011}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700827 / DSM 18053 / CIP 107007 / KCTC 52180 / NS114
RC {ECO:0000313|Proteomes:UP000002011};
RX PubMed=21304649; DOI=10.4056/sigs.19262;
RA Lang E., Lapidus A., Chertkov O., Brettin T., Detter J.C., Han C.,
RA Copeland A., Glavina Del Rio T., Nolan M., Chen F., Lucas S., Tice H.,
RA Cheng J.F., Land M., Hauser L., Chang Y.J., Jeffries C.D., Kopitz M.,
RA Bruce D., Goodwin L., Pitluck S., Ovchinnikova G., Pati A., Ivanova N.,
RA Mavrommatis K., Chen A., Palaniappan K., Chain P., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Goker M., Rohde M., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Dyadobacter fermentans type strain (NS114).";
RL Stand. Genomic Sci. 1:133-140(2009).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP001619; ACT94198.1; -; Genomic_DNA.
DR RefSeq; WP_015812447.1; NC_013037.1.
DR AlphaFoldDB; C6W5I0; -.
DR STRING; 471854.Dfer_2983; -.
DR KEGG; dfe:Dfer_2983; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_3_1_10; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000002011; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000002011}.
FT DOMAIN 688..704
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 614..621
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 864 AA; 96862 MW; AF6842435E24F189 CRC64;
MAKAHKETPL NKQYNQIKAK YPGALLLFRV GDFYETFGED AVRASKILGI VLTRRNNGGA
HEELAGFPHH SLDNYLPKLV RAGERVAICD QLEDPAAAKG IVKRGVTELV TPGVSFNDNV
LDIRKNNYLA AVHVGSDGLY GIAFLDISTG EFMASQGNAA YIDKMLQGFG PAEVLYCKKH
KQEFNELFGG KYHTFHLEDW CFGYDYGYEQ LTGHFQTTTL KGYGVESLPL GIIAAGVVLH
YLRETEHKEV AHISRITRLE EEKYVWLDRF TVRNLELVYA QQEGGVPLID ILDHTVTPMG
ARQLRKWMVL PLKDKAPIEE RLSAVEHFLA SEELHESLVG YFKQIGDLER LISKVAVRRI
NPRELVQLKK SLKQVAPVKQ LLAGGILDKF ASQLDACGAL VEKIDKELRD DAPVLSNQGR
MVQSGVDSEL DELHAISYEG KDYLIKLQNR EIERTGISSL KIAYNKVFGY YLEVTHAHQS
KVPADWIRKQ TLVNAERYIT PELKEYEEKI MNAEDRISAI EFRIFSELVQ KAAEFVGAIQ
QNALVISALD VLSSFALAAR KNKYAKPVIS EGNELDIKEG RHPVIEQQLP VGESYVPNDV
YLDDSSQQII IITGPNMAGK SALLRQTALI VLMAQMGSFV PARSATVGIV DKVFTRVGAS
DNLSRGESTF MVEMTETASI LNNLSSKSLV LMDEIGRGTS TYDGVSIAWA ITEYLHNQSD
CRPKTLFATH YHELNQLAED FPRIKNFNVA VKEVDNKVVF LRKLKPGGSA HSFGIHVAQI
AGMPQPIVLR ASEIMQHLEK DHVAHEHKKR VKDIPKNNFQ LSIFEPADPR LDELKEKLLL
VDVNTLSPIE ALLKLNEFQK LIKK
//
