ID   C6WPE9_ACTMD            Unreviewed;       308 AA.
AC   C6WPE9;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 76.
DE   SubName: Full=Transcriptional regulator, LysR family {ECO:0000313|EMBL:ACU38651.1};
GN   OrderedLocusNames=Amir_4824 {ECO:0000313|EMBL:ACU38651.1};
OS   Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064
OS   / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101).
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Actinosynnema.
OX   NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU38651.1, ECO:0000313|Proteomes:UP000002213};
RN   [1] {ECO:0000313|EMBL:ACU38651.1, ECO:0000313|Proteomes:UP000002213}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 /
RC   NRRL B-12336 / IMRU 3971 / 101 {ECO:0000313|Proteomes:UP000002213};
RX   PubMed=21304636; DOI=10.4056/sigs.21137;
RA   Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA   Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D., Goodwin L.,
RA   Pitluck S., Rohde M., Goker M., Pati A., Ivanova N., Mavromatis K.,
RA   Chen A., Palaniappan K., Hauser L., Chang Y.J., Jeffries C.C., Brettin T.,
RA   Detter J.C., Han C., Chain P., Tindall B.J., Bristow J., Eisen J.A.,
RA   Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL   Stand. Genomic Sci. 1:46-53(2009).
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000256|ARBA:ARBA00009437}.
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DR   EMBL; CP001630; ACU38651.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6WPE9; -.
DR   STRING; 446462.Amir_4824; -.
DR   KEGG; ami:Amir_4824; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_6_0_11; -.
DR   Proteomes; UP000002213; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd08423; PBP2_LTTR_like_6; 1.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30126; HTH-TYPE TRANSCRIPTIONAL REGULATOR; 1.
DR   PANTHER; PTHR30126:SF6; HTH-TYPE TRANSCRIPTIONAL REGULATOR CYSB-RELATED; 1.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002213};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          15..67
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50931"
SQ   SEQUENCE   308 AA;  33648 MW;  AC986200C00D80C8 CRC64;
     MWPNKNGGVL NPWRLRLLSQ LETLGTVRAV AEAASLSAST VSQQLSVLEA ETRTRLLERT
     GRRVRLTSAG QLLARRAREI LDHMDTVEAE LLGLGGEPAG LVRVGTFQSG IHTLAVPAVL
     QLARSHPHLQ VELLELEPHE SLRALRVGDA DLVITTADFV EVPLGPDLDV VPLAVDPVVL
     VLPQHRGARG PVDLAAFADE PWALDVPGSY MANLTTRLCR QAGFEPRVVC RFSNYLMTLQ
     HVEAGLSVAL LPALAVDERY RLVRRELVPE VTRTITAVVR RGARRPAGVE LVLETLRRLP
     TPPGISRP
//