ID C6WPG9_ACTMD Unreviewed; 434 AA.
AC C6WPG9;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Sterol 3-beta-glucosyltransferase {ECO:0000313|EMBL:ACU38671.1};
DE EC=2.4.1.173 {ECO:0000313|EMBL:ACU38671.1};
GN OrderedLocusNames=Amir_4844 {ECO:0000313|EMBL:ACU38671.1};
OS Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064
OS / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinosynnema.
OX NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU38671.1, ECO:0000313|Proteomes:UP000002213};
RN [1] {ECO:0000313|EMBL:ACU38671.1, ECO:0000313|Proteomes:UP000002213}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 /
RC NRRL B-12336 / IMRU 3971 / 101 {ECO:0000313|Proteomes:UP000002213};
RX PubMed=21304636; DOI=10.4056/sigs.21137;
RA Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D., Goodwin L.,
RA Pitluck S., Rohde M., Goker M., Pati A., Ivanova N., Mavromatis K.,
RA Chen A., Palaniappan K., Hauser L., Chang Y.J., Jeffries C.C., Brettin T.,
RA Detter J.C., Han C., Chain P., Tindall B.J., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL Stand. Genomic Sci. 1:46-53(2009).
CC -!- PATHWAY: Antibiotic biosynthesis; vancomycin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004660}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 28 family.
CC {ECO:0000256|ARBA:ARBA00006962}.
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DR EMBL; CP001630; ACU38671.1; -; Genomic_DNA.
DR RefSeq; WP_015803558.1; NC_013093.1.
DR AlphaFoldDB; C6WPG9; -.
DR STRING; 446462.Amir_4844; -.
DR CAZy; GT1; Glycosyltransferase Family 1.
DR KEGG; ami:Amir_4844; -.
DR eggNOG; COG1819; Bacteria.
DR HOGENOM; CLU_000537_8_0_11; -.
DR OrthoDB; 3253247at2; -.
DR UniPathway; UPA00162; -.
DR Proteomes; UP000002213; Chromosome.
DR GO; GO:0102203; F:brassicasterol glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0102205; F:cholesterol alpha-glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0102202; F:soladodine glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0016906; F:sterol 3-beta-glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0030259; P:lipid glycosylation; IEA:InterPro.
DR GO; GO:0033072; P:vancomycin biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR010610; EryCIII-like_C.
DR InterPro; IPR004276; GlycoTrans_28_N.
DR InterPro; IPR002213; UDP_glucos_trans.
DR PANTHER; PTHR48050; STEROL 3-BETA-GLUCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR48050:SF13; UDP-GLUCURONOSYLTRANSFERASE; 1.
DR Pfam; PF06722; EryCIII-like_C; 1.
DR Pfam; PF03033; Glyco_transf_28; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Glycosyltransferase {ECO:0000313|EMBL:ACU38671.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002213};
KW Transferase {ECO:0000313|EMBL:ACU38671.1}.
FT DOMAIN 3..52
FT /note="Glycosyltransferase family 28 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03033"
FT DOMAIN 305..408
FT /note="Erythromycin biosynthesis protein CIII-like C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF06722"
SQ SEQUENCE 434 AA; 46962 MW; E04CFC5E9CA282C2 CRC64;
MRILIYTYGT RGDVQPYVAL AVALNARGHH CVLSAPARFA GLAAAHGVEF AGRDDELIRF
YLEDPEVQYS LAHQGSAEPG FRARGRRAST ALRRTLVARL PHILRDTAAA AEGGADLVVA
GHYQWELGQH IAEHLKAPLV MTSLWPTCLP SRRHPSEVVP FGGSLPPLLN RLSYLPLRWF
QVGGAEVDRW RADLGLPKRR GRHDRSRTAT GEPVPFVHGI SPLVVPPAPD WPANAHTSGF
WRLPPAPDWS PPPSLADFLD RDPKPVFIGF GSIVSRDPED TARVIREAVS RAGVRAVVRL
EANIDADALG PDVLPAGEAP YDWLFPRVAA IVHGGGVGTV NDALASGVPQ VPVPHTSEQE
VWCRIAHRLG VATEPFRQRD LDVDRLATAL RAATGDEGLA RAARSVGERV RAEDGAGTAA
ALVERYGLDR AATR
//
