ID C6WSA4_ACTMD Unreviewed; 326 AA.
AC C6WSA4;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Transcriptional regulator, LacI family {ECO:0000313|EMBL:ACU38924.1};
DE EC=5.1.1.1 {ECO:0000313|EMBL:ACU38924.1};
GN OrderedLocusNames=Amir_5102 {ECO:0000313|EMBL:ACU38924.1};
OS Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064
OS / NCIMB 13271 / NRRL B-12336 / IMRU 3971 / 101).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Actinosynnema.
OX NCBI_TaxID=446462 {ECO:0000313|EMBL:ACU38924.1, ECO:0000313|Proteomes:UP000002213};
RN [1] {ECO:0000313|EMBL:ACU38924.1, ECO:0000313|Proteomes:UP000002213}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29888 / DSM 43827 / JCM 3225 / NBRC 14064 / NCIMB 13271 /
RC NRRL B-12336 / IMRU 3971 / 101 {ECO:0000313|Proteomes:UP000002213};
RX PubMed=21304636; DOI=10.4056/sigs.21137;
RA Land M., Lapidus A., Mayilraj S., Chen F., Copeland A., Del Rio T.G.,
RA Nolan M., Lucas S., Tice H., Cheng J.F., Chertkov O., Bruce D., Goodwin L.,
RA Pitluck S., Rohde M., Goker M., Pati A., Ivanova N., Mavromatis K.,
RA Chen A., Palaniappan K., Hauser L., Chang Y.J., Jeffries C.C., Brettin T.,
RA Detter J.C., Han C., Chain P., Tindall B.J., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Actinosynnema mirum type strain (101).";
RL Stand. Genomic Sci. 1:46-53(2009).
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DR EMBL; CP001630; ACU38924.1; -; Genomic_DNA.
DR RefSeq; WP_015803811.1; NC_013093.1.
DR AlphaFoldDB; C6WSA4; -.
DR STRING; 446462.Amir_5102; -.
DR KEGG; ami:Amir_5102; -.
DR eggNOG; COG1609; Bacteria.
DR HOGENOM; CLU_037628_6_0_11; -.
DR OrthoDB; 3258243at2; -.
DR Proteomes; UP000002213; Chromosome.
DR GO; GO:0008784; F:alanine racemase activity; IEA:UniProtKB-EC.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01392; HTH_LacI; 1.
DR CDD; cd06267; PBP1_LacI_sugar_binding-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR046335; LacI/GalR-like_sensor.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR30146; LACI-RELATED TRANSCRIPTIONAL REPRESSOR; 1.
DR PANTHER; PTHR30146:SF109; TRANSCRIPTIONAL REGULATOR LACI_GALR-LIKE SENSOR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF13377; Peripla_BP_3; 1.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00356; HTH_LACI_1; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000313|EMBL:ACU38924.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002213};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 8..62
FT /note="HTH lacI-type"
FT /evidence="ECO:0000259|PROSITE:PS50932"
SQ SEQUENCE 326 AA; 33957 MW; 74E1F5621311E0FD CRC64;
MPVTTRPVTI RDVARQAQVS VSTVSRALTA PELVRAETRV RVLEIADRLG YQPNPAARSL
ITGRTGNLGI VVPDLGNPFY PGVMRGAQAS ARDSGRSVFF CDSGGSARQE AALVRSLAPQ
VDGLVLCSPL TGGAELAELV ALRTTVLLNR PLPGVSSVLM DSRSGAEAAL ARLALLGHQR
CAYLGGPDES WTNGERLAGL RSASDEHGVG LRALGPFPPS FAGGELGADE ALGAGVTALV
AYNDLMALGA LQRLRERGVA VPDRMAVIGF DDLLYSAVCH PSLTTVALPM EEGGRAAVRE
LLARLAGEPP STRVLPTALR VRASTG
//
