ID C6X138_FLAB3 Unreviewed; 572 AA.
AC C6X138;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=FIC_01708 {ECO:0000313|EMBL:ACU08151.1};
OS Flavobacteriaceae bacterium (strain 3519-10).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae.
OX NCBI_TaxID=531844 {ECO:0000313|EMBL:ACU08151.1, ECO:0000313|Proteomes:UP000001512};
RN [1] {ECO:0000313|EMBL:ACU08151.1, ECO:0000313|Proteomes:UP000001512}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3519-10 {ECO:0000313|EMBL:ACU08151.1,
RC ECO:0000313|Proteomes:UP000001512};
RX PubMed=18622572; DOI=10.1007/s00792-008-0178-2;
RA Raymond J.A., Christner B.C., Schuster S.C.;
RT "A bacterial ice-binding protein from the Vostok ice core.";
RL Extremophiles 12:713-717(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP001673; ACU08151.1; -; Genomic_DNA.
DR AlphaFoldDB; C6X138; -.
DR STRING; 531844.FIC_01708; -.
DR KEGG; fba:FIC_01708; -.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_472284_0_0_10; -.
DR Proteomes; UP000001512; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR43047:SF82; SIGNAL TRANSDUCTION HISTIDINE-PROTEIN KINASE ARLS; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001512};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 15..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 349..570
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 572 AA; 65553 MW; F566A19E8CD502D5 CRC64;
MTINSMTENR NNRPLVHYSL IAATLLIQVV IAVFIYNEYF NQKKLESIES QLRDSRTLEK
AAREARTDLL QAQNHLQLYM DTQGRENLEA YFASLRKLSR NLDSISGSPD LNPELAKLIQ
RKKSELTSLP DLDGLIRSVY QESQKPKSER KPIVIKEINI PAPATSYRTD IERRADTLAK
KPLLSRLKDA INNETEVQRE VVLVTTNRTD SLDTSKIRTD MDSIVRNLQS HYQDEIRKYE
AGIVSARQQS DNLYRTYDQL IRISNNWMEV YTYAIGDYNA KLQEQLDDQR SVNSQVRRYT
LVGLIVLMFL VLLLIIYFTR QSFEYQRELR AANAEIRNNL KFKNRVLGML SHEVLAPLKI
INLFIDRISR KNGDSVIEGH LQSMKFTNSS LLIQAGQILE YAKNQERKPV LHPEKFNLFN
ETERILQVFG PFIESRNNVF EVENTIPADT AVFADKILIY QLFTNILGNA NKFTENGRIA
VSTRISSEEK LRYRMDVTVA DTGSGISSAD LKRIFEPYYQ GQSSAGPENI GAGLGLNLCR
ETVELLGGKI WAESQSGRGT TINFYIHLDK ES
//
