ID   C6XNE0_HIRBI            Unreviewed;       351 AA.
AC   C6XNE0;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|Pfam:PF13676};
GN   OrderedLocusNames=Hbal_2404 {ECO:0000313|EMBL:ACT60084.1};
OS   Hirschia baltica (strain ATCC 49814 / DSM 5838 / IFAM 1418).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomonadales;
OC   Hyphomonadaceae; Hirschia.
OX   NCBI_TaxID=582402 {ECO:0000313|EMBL:ACT60084.1, ECO:0000313|Proteomes:UP000002745};
RN   [1] {ECO:0000313|Proteomes:UP000002745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49814 / DSM 5838 / IFAM 1418
RC   {ECO:0000313|Proteomes:UP000002745};
RX   PubMed=21705585; DOI=10.1128/JB.05453-11;
RG   US DOE Joint Genome Institute;
RA   Brown P.J., Kysela D.T., Buechlein A., Hemmerich C., Brun Y.V.;
RT   "Genome sequences of eight morphologically diverse alphaproteobacteria.";
RL   J. Bacteriol. 193:4567-4568(2011).
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DR   EMBL; CP001678; ACT60084.1; -; Genomic_DNA.
DR   RefSeq; WP_015828234.1; NC_012982.1.
DR   AlphaFoldDB; C6XNE0; -.
DR   STRING; 582402.Hbal_2404; -.
DR   KEGG; hba:Hbal_2404; -.
DR   eggNOG; COG4916; Bacteria.
DR   HOGENOM; CLU_787151_0_0_5; -.
DR   OrthoDB; 105971at2; -.
DR   Proteomes; UP000002745; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   Pfam; PF13676; TIR_2; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002745};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        145..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          4..113
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|Pfam:PF13676"
SQ   SEQUENCE   351 AA;  39390 MW;  2BCD697565686464 CRC64;
     MADIFISYKK EDAGRVVRIV EGLREAGFSV WWDHGIAPGS QWDQTIQKEL TEAKMVIAVW
     SELSISAPWV KEEAGVGKAR GKLLPVRIDE VDPPLGFGLI QMANLIDWDG DTNDQHWEHF
     LAAAKATLSG EPVEGLERPV KRKSVWLKML PILALIALVV GVGIFVLTKL DSILGVSVDY
     DNGTSSEYSR KSATPSQAES DLFEKAGQST LKADYLDYLK IYPQGTFAKK IREEILPFCS
     YEQRDKWIPI PMPAGQMIRA TSDTSVYDLE KQIFTDLEAA CSMAQSNFER QVEKLCKNFT
     SSPNSRNPEL TVTHADKCDC QEFNGEWMCF TDSTYACSWE TKSFENVEVC K
//