ID C6Y423_PEDHD Unreviewed; 642 AA.
AC C6Y423;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Sulfatase {ECO:0000313|EMBL:ACU05466.1};
GN OrderedLocusNames=Phep_3271 {ECO:0000313|EMBL:ACU05466.1};
OS Pedobacter heparinus (strain ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457
OS / NBRC 12017 / NCIMB 9290 / NRRL B-14731 / HIM 762-3).
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae; Pedobacter.
OX NCBI_TaxID=485917 {ECO:0000313|EMBL:ACU05466.1, ECO:0000313|Proteomes:UP000000852};
RN [1] {ECO:0000313|EMBL:ACU05466.1, ECO:0000313|Proteomes:UP000000852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13125 / DSM 2366 / CIP 104194 / JCM 7457 / NBRC 12017 /
RC NCIMB 9290 / NRRL B-14731 / HIM 762-3
RC {ECO:0000313|Proteomes:UP000000852};
RX PubMed=21304637; DOI=10.4056/sigs.22138;
RA Han C., Spring S., Lapidus A., Del Rio T.G., Tice H., Copeland A.,
RA Cheng J.F., Lucas S., Chen F., Nolan M., Bruce D., Goodwin L., Pitluck S.,
RA Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A., Palaniappan K.,
RA Land M., Hauser L., Chang Y.J., Jeffries C.C., Saunders E., Chertkov O.,
RA Brettin T., Goker M., Rohde M., Bristow J., Eisen J.A., Markowitz V.,
RA Hugenholtz P., Kyrpides N.C., Klenk H.P., Detter J.C.;
RT "Complete genome sequence of Pedobacter heparinus type strain (HIM 762-
RT 3).";
RL Stand. Genomic Sci. 1:54-62(2009).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001681; ACU05466.1; -; Genomic_DNA.
DR RefSeq; WP_015809075.1; NZ_AQGK01000001.1.
DR AlphaFoldDB; C6Y423; -.
DR STRING; 485917.Phep_3271; -.
DR KEGG; phe:Phep_3271; -.
DR eggNOG; COG1368; Bacteria.
DR HOGENOM; CLU_014653_3_1_10; -.
DR OrthoDB; 9777768at2; -.
DR Proteomes; UP000000852; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16015; LTA_synthase; 1.
DR Gene3D; 3.30.1120.80; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR012160; LtaS-like.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR47371; LIPOTEICHOIC ACID SYNTHASE; 1.
DR PANTHER; PTHR47371:SF3; PHOSPHOGLYCEROL TRANSFERASE I; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR PIRSF; PIRSF005091; Mmb_sulf_HI1246; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Manganese {ECO:0000256|PIRSR:PIRSR005091-2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR005091-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000852};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 273..547
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT ACT_SITE 326
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-1"
FT BINDING 280
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 441
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-2"
FT BINDING 495
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
FT BINDING 496
FT /ligand="Mn(2+)"
FT /ligand_id="ChEBI:CHEBI:29035"
FT /evidence="ECO:0000256|PIRSR:PIRSR005091-3"
SQ SEQUENCE 642 AA; 74032 MW; ACFCC5C9AFC0B93D CRC64;
MKRENPITLN LYVALAYRFL ILLVLYTLCR LGFFFFNHSL FQHITLPKYL YMLWGGLKFD
VSALIYINAI FLLMQLVPAP FKYKDGYQRF CKWLFIISNS IGIMANFADF AYYKYTLKRT
TATVFSQFSH EQNKFKLFID FLTDYWYLFL LYALFIWGFV KLYQLVGVKK VKTFKWPAYL
LQTVLLFAIA LVCLTGVRGG WGYGTRPITL SNAGEFVDTP DQMSLVLNTP FCIFRTLKVS
KLKPVNYYDE QTLNSIYNPI HLPKDTVAFK KLNVVFLIIE SLGKEHIGGL NKDLMGGKYK
GFTPFIDSLI EQSYTFTHTY ANGRKSIDAL PSVISGIPSI REPFVLSVYS GNKTTSIAKL
LGDKGYETAF FHGAPNGSMG FSSYTHLAGI KHYFGQNEYK KTGDYDGTWG IWDNPFMQYM
AQTMNTLKQP FFSAFFSLSS HHPFKLPDEY AGKFPKGHLP VQEVLGYTDM ALRNFFRTAS
AMPWYKNTLF VLCADHATVS YFPEYQTTPG YFSIPIVFYY PGGDLKGKAD KNVQQIDIMP
TVLNYLHYDK PYFALGFDAF DKRQDNFVVN NNDGTFSFYQ GDYLLINDGK INLSLYNLKT
DRLTQNNILD KEPLIAQQME KYLKAFVQQY NNRMIENKLT AN
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