ID C6YSK0_9GAMM Unreviewed; 571 AA.
AC C6YSK0;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=Aspartate-alanine antiporter {ECO:0000313|EMBL:AJI75470.1};
GN Name=aspT {ECO:0000313|EMBL:AJI75470.1};
GN ORFNames=BZ13_1556 {ECO:0000313|EMBL:AJI75470.1};
OS Francisella philomiragia subsp. philomiragia ATCC 25015.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Francisellaceae; Francisella.
OX NCBI_TaxID=539329 {ECO:0000313|EMBL:AJI75470.1, ECO:0000313|Proteomes:UP000031897};
RN [1] {ECO:0000313|EMBL:AJI75470.1, ECO:0000313|Proteomes:UP000031897}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O#319L {ECO:0000313|EMBL:AJI75470.1,
RC ECO:0000313|Proteomes:UP000031897};
RX PubMed=25931589;
RA Johnson S.L., Daligault H.E., Davenport K.W., Coyne S.R., Frey K.G.,
RA Koroleva G.I., Broomall S.M., Bishop-Lilly K.A., Bruce D.C., Chertkov O.,
RA Freitas T., Jaissle J., Ladner J.T., Rosenzweig C.N., Gibbons H.S.,
RA Palacios G.F., Redden C.L., Xu Y., Minogue T.D., Chain P.S.;
RT "Genome sequencing of 18 francisella strains to aid in assay development
RT and testing.";
RL Genome Announc. 3:0-0(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the AAE transporter (TC 2.A.81) family.
CC {ECO:0000256|ARBA:ARBA00009854}.
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DR EMBL; CP010019; AJI75470.1; -; Genomic_DNA.
DR RefSeq; WP_004286505.1; NZ_DS999311.1.
DR AlphaFoldDB; C6YSK0; -.
DR KEGG; fpt:BZ13_1556; -.
DR PATRIC; fig|539329.6.peg.1527; -.
DR HOGENOM; CLU_035023_2_2_6; -.
DR Proteomes; UP000031897; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR022457; Asp_Ala_antiprt.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR006512; YidE_YbjL.
DR NCBIfam; TIGR03802; Asp_Ala_antiprt; 1.
DR PANTHER; PTHR30445:SF8; TRANSPORT PROTEIN YBJL-RELATED; 1.
DR PANTHER; PTHR30445; UNCHARACTERIZED; 1.
DR Pfam; PF06826; Asp-Al_Ex; 2.
DR Pfam; PF02080; TrkA_C; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 411..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 455..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 551..569
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 16..182
FT /note="YidE/YbjL duplication"
FT /evidence="ECO:0000259|Pfam:PF06826"
FT DOMAIN 311..380
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02080"
FT DOMAIN 394..563
FT /note="YidE/YbjL duplication"
FT /evidence="ECO:0000259|Pfam:PF06826"
SQ SEQUENCE 571 AA; 62172 MW; B06AF32BC5CFFEDD CRC64;
MVLQLVLNIL KNPFIALFLT VSIGYLLGKI KYKTFVLGGI SGSLIIGVII GQLNIMIPPE
IGSLFFALFI YAVGYQGGAQ FFRSLNKSTL LLLASSTITC LLGLICVLTF AWIFGLDKGT
AAGLGAGGLT QSAMIGSANN AIAAISSLPE SIIHTMQANV AVGYAVCYIF GSFGPIILLA
TIFPLIMKWD IRKEAIKLAT EQSDGSLDLE AGQFSAFSEY TTRAYRISHN SELLNKSVIE
IYKAYEYKVV IENIIRNDKL LTITPKTTIH TDDIVAITFY KDLDIQSIIS NDDEVTKPEQ
FNFIEEKRSL ILTNKNLFNK TIQEIKTIIQ DKNYYGVFLQ KIIRSGQKLP ISDELKLRRG
DEIVLVGKPE DLDKISNKIG TYISEAPITD FIFFGLGMVL GYILGLISFN IFGISITLGA
GVGCLLSGLI FGWIRSVKPQ FSNLPLGASN FIRDFGLAIF VASVGITAGP QAIIAIKEHG
LTLFFLGIGV TIIPQVISFY ISYYLLKIKN PIVLLATIAG GRSANPGFAA LLERAGNATP
VIPFTSSYAL ANIWLTLWGP IIVALVTIIP K
//
