ID C6ZFA4_9ENTO Unreviewed; 593 AA.
AC C6ZFA4;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
DE Flags: Fragment;
OS rhinovirus A65.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Picornaviridae; Ensavirinae; Enterovirus; Rhinovirus A.
OX NCBI_TaxID=44135 {ECO:0000313|EMBL:ACU27208.1};
RN [1] {ECO:0000313|EMBL:ACU27208.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19402957; DOI=10.3201/eid1505.081286;
RA Tapparel C., Junier T., Gerlach D., Van-Belle S., Turin L., Cordey S.,
RA Muhlemann K., Regamey N., Aubert J.D., Soccal P.M., Eigenmann P.,
RA Zdobnov E., Kaiser L.;
RT "New respiratory enterovirus and recombinant rhinoviruses among circulating
RT picornaviruses.";
RL Emerg. Infect. Dis. 15:719-726(2009).
CC -!- SUBUNIT: Interacts with RNA-directed RNA polymerase.
CC {ECO:0000256|ARBA:ARBA00011124}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}.
CC -!- SIMILARITY: Belongs to the picornaviruses polyprotein family.
CC {ECO:0000256|ARBA:ARBA00008303}.
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DR EMBL; EU840840; ACU27208.1; -; Genomic_RNA.
DR MEROPS; C03.007; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0039618; C:T=pseudo3 icosahedral viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR Gene3D; 1.20.960.20; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 4.10.880.10; Poliovirus 3D polymerase Domain 1 (Nucleotidyltransferase); 2.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR044067; PCV_3C_PRO.
DR InterPro; IPR000199; Peptidase_C3A/C3B_picornavir.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF00548; Peptidase_C3; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51874; PCV_3C_PRO; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Capsid protein {ECO:0000256|ARBA:ARBA00022706};
KW Covalent protein-RNA linkage {ECO:0000256|ARBA:ARBA00022520};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW T=pseudo3 icosahedral capsid protein {ECO:0000256|ARBA:ARBA00022706};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Virion {ECO:0000256|ARBA:ARBA00022706}.
FT DOMAIN 6..184
FT /note="Peptidase C3"
FT /evidence="ECO:0000259|PROSITE:PS51874"
FT DOMAIN 415..528
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACU27208.1"
FT NON_TER 593
FT /evidence="ECO:0000313|EMBL:ACU27208.1"
SQ SEQUENCE 593 AA; 66690 MW; ED653A975B9402DB CRC64;
RVVTQGPQEE FGRSLLKHNA CIVTTDNGKF TGLGIYDNVM ILPTHADAGK TIDINGIQTR
VADAYDLYNS QGVKLEITVV KLDRNEKFRD IRKYIPDTED DYPECCLALL ANQPEPTIIE
VGDSCSYGNI LLSGNQTARM IKYNYPTKSG FCGGVLYKIG LVLGIHVGGN GRNGFSAMLL
RSYFNEQQGQ IMSRADVREK NLFSIHTPTK TKLQPSVFHD TFPGKKEPAV LSSKDPRLQV
DLEESIFSKY KGNKQIEITQ NMRVAAAHYT AQLSTLDISP EPLSMEESVY GIEGLEALDL
HTSAGYPYTA CGIKKKDLIP KDKNLTKLKQ AMEKYGLDLP MITFLKDELR KPDKIYTGKT
RIIEASSLND TVQFRMAFGR LFSSFHQNPG IITGSAVGCD PETFWSKIPV MLDGECLMAF
DYSNYDGSLN PVWFKLLAQI LENLGFPGNL VQKLCYSKHI FKTQYYEVEG GMPSGCAGTS
IFNTMINNVI IRTLVLDTYK YVNLDKLKIL AYGDDILFSY PYDLDMKELA DEGLKYGLTI
TPADKSDVFK KLDFGNATFL KRGFRPDEKH SFLIHPVYPE EEVWESIRWT KNP
//
