ID C6ZFD1_9ENTO Unreviewed; 591 AA.
AC C6ZFD1;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
DE Flags: Fragment;
OS rhinovirus A96.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Picornaviridae; Ensavirinae; Enterovirus; Rhinovirus A.
OX NCBI_TaxID=185943 {ECO:0000313|EMBL:ACU27235.1};
RN [1] {ECO:0000313|EMBL:ACU27235.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19402957; DOI=10.3201/eid1505.081286;
RA Tapparel C., Junier T., Gerlach D., Van-Belle S., Turin L., Cordey S.,
RA Muhlemann K., Regamey N., Aubert J.D., Soccal P.M., Eigenmann P.,
RA Zdobnov E., Kaiser L.;
RT "New respiratory enterovirus and recombinant rhinoviruses among circulating
RT picornaviruses.";
RL Emerg. Infect. Dis. 15:719-726(2009).
CC -!- SUBUNIT: Interacts with RNA-directed RNA polymerase.
CC {ECO:0000256|ARBA:ARBA00011124}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}.
CC -!- SIMILARITY: Belongs to the picornaviruses polyprotein family.
CC {ECO:0000256|ARBA:ARBA00008303}.
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DR EMBL; EU840867; ACU27235.1; -; Genomic_RNA.
DR MEROPS; C03.007; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0039618; C:T=pseudo3 icosahedral viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR Gene3D; 1.20.960.20; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 4.10.880.10; Poliovirus 3D polymerase Domain 1 (Nucleotidyltransferase); 2.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR044067; PCV_3C_PRO.
DR InterPro; IPR000199; Peptidase_C3A/C3B_picornavir.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF00548; Peptidase_C3; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51874; PCV_3C_PRO; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Capsid protein {ECO:0000256|ARBA:ARBA00022706};
KW Covalent protein-RNA linkage {ECO:0000256|ARBA:ARBA00022520};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW T=pseudo3 icosahedral capsid protein {ECO:0000256|ARBA:ARBA00022706};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Virion {ECO:0000256|ARBA:ARBA00022706}.
FT DOMAIN 6..184
FT /note="Peptidase C3"
FT /evidence="ECO:0000259|PROSITE:PS51874"
FT DOMAIN 416..529
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACU27235.1"
FT NON_TER 591
FT /evidence="ECO:0000313|EMBL:ACU27235.1"
SQ SEQUENCE 591 AA; 66368 MW; 1B2E7E63DC52582A CRC64;
RVVAQGPEEE FGRSLIKHNT CVVTTDNGKF TGLGIYDRLM ILPTHADPGK EISINGIVTK
VSDSYDMYNK QGIKLEITAV VLDRNEKFRD IRKYIPEGED DYPECNLALV ANQPEPTIIN
VGDVISYGNI LLSGTQTARM LKYNYPTKSG YCGGVLYKIG QIIGIHVGGN GRDGFSAMLL
RSYFSETQGE IKTTKKVNEC GYPTIHTPAK TKLQPSVFFD VFEGSKEPAV LSEKDPRLKT
DFNQALFSKY KGNVNCDMSE HMKVAVSHYS AQLMTLDIDP SNITLEESVF GTEGLEALDL
NTSAGFPYIS MGIRKRDLIN NNTKDITKLK IALDKYGVDL PMVTFLKDEL RKKEKISAGK
TRVIEASSIN DTVAFRMVYG RLFSTFHKNP GIITGSAVGC DPETFWSKIP VMLDGECIMA
FDYTNYDGSI HPVWFEALKQ VLLNLSFEHR LIDRLCNSKH IFKDTYYEVE GGIPSGCSGT
SIFNTMINNV IIRTLVLDAY KHIDLDKLKI IAYGDDVIFS YKYPLDMEAI ALEGNKYGLT
ITPADKSDTF KKLDYNSVTF LKRGFKQDDK YPFLIHPTFP ISEIHESIRW T
//
