ID C6ZGH4_RAT Unreviewed; 395 AA.
AC C6ZGH4;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=Intermediate conductance K channel isoform 4c {ECO:0000313|EMBL:ACJ61218.1};
GN Name=Kcnn4 {ECO:0000313|RGD:621476};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|EMBL:ACJ61218.1};
RN [1] {ECO:0000313|EMBL:ACJ61218.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Sprague-Dawley {ECO:0000313|EMBL:ACJ61218.1};
RC TISSUE=Colon {ECO:0000313|EMBL:ACJ61218.1};
RX PubMed=20445171; DOI=10.1152/ajpcell.00091.2009;
RA Barmeyer C., Rahner C., Yang Y., Sigworth F.J., Binder H.J.,
RA Rajendran V.M.;
RT "Cloning and identification of tissue-specific expression of KCNN4 splice
RT variants in rat colon.";
RL Am. J. Physiol. Cell Physiol. 299:C251-C263(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; EU872451; ACJ61218.1; -; mRNA.
DR RefSeq; NP_001257631.1; NM_001270702.1.
DR AlphaFoldDB; C6ZGH4; -.
DR GeneID; 65206; -.
DR CTD; 3783; -.
DR RGD; 621476; Kcnn4.
DR OrthoDB; 4200919at2759; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR GO; GO:0016286; F:small conductance calcium-activated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR InterPro; IPR004178; CaM-bd_dom.
DR InterPro; IPR036122; CaM-bd_dom_sf.
DR InterPro; IPR015449; K_chnl_Ca-activ_SK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR10153:SF41; INTERMEDIATE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 4; 1.
DR PANTHER; PTHR10153; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02888; CaMBD; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR Pfam; PF03530; SK_channel; 1.
DR SMART; SM01053; CaMBD; 1.
DR SUPFAM; SSF81327; Small-conductance potassium channel; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 2: Evidence at transcript level;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 25..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 273..346
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000259|SMART:SM01053"
SQ SEQUENCE 395 AA; 44322 MW; D825B43180CEB1D5 CRC64;
MGGELVTGLG ALRRRKRLLE QEKRVAGWAL VLAGTGIGLM VLHAEMLWFL GCKEVQLFMT
DNGLRDWRVA LTRRQVAQIL LELLVCGVHP VPLRSPHCTL AGEATDSQAW PGFLGEGEAL
LSLAMLLRLY LVPRAVLLRS GVLLNASYRS IGALNQVRFR HWFVAKLYMN THPGRLLLGL
TLGLWLTTAW VLSVAERQAV NATGHLTDTL WLIPITFLTI GYGDVVPGTL WGKIVCLCTG
VMGVCCTALL VAVVARKLEF NKAEKHVHNF MMDIHYAKEM KESAARLLQE AWMYYKHTRR
KDSRAARRHQ RKMLAAIHTF RQVRLKHRKL REQVNSMVDI SKMHMILCDL QLGLSASHLA
LEKRIDGLAG KLDALTELLS TALQQQPPEP IQEAT
//