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Database: UniProt
Entry: C6ZGH4_RAT
LinkDB: C6ZGH4_RAT
Original site: C6ZGH4_RAT 
ID   C6ZGH4_RAT              Unreviewed;       395 AA.
AC   C6ZGH4;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   24-JAN-2024, entry version 54.
DE   SubName: Full=Intermediate conductance K channel isoform 4c {ECO:0000313|EMBL:ACJ61218.1};
GN   Name=Kcnn4 {ECO:0000313|RGD:621476};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:ACJ61218.1};
RN   [1] {ECO:0000313|EMBL:ACJ61218.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sprague-Dawley {ECO:0000313|EMBL:ACJ61218.1};
RC   TISSUE=Colon {ECO:0000313|EMBL:ACJ61218.1};
RX   PubMed=20445171; DOI=10.1152/ajpcell.00091.2009;
RA   Barmeyer C., Rahner C., Yang Y., Sigworth F.J., Binder H.J.,
RA   Rajendran V.M.;
RT   "Cloning and identification of tissue-specific expression of KCNN4 splice
RT   variants in rat colon.";
RL   Am. J. Physiol. Cell Physiol. 299:C251-C263(2010).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; EU872451; ACJ61218.1; -; mRNA.
DR   RefSeq; NP_001257631.1; NM_001270702.1.
DR   AlphaFoldDB; C6ZGH4; -.
DR   GeneID; 65206; -.
DR   CTD; 3783; -.
DR   RGD; 621476; Kcnn4.
DR   OrthoDB; 4200919at2759; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005516; F:calmodulin binding; IEA:InterPro.
DR   GO; GO:0016286; F:small conductance calcium-activated potassium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 2.
DR   InterPro; IPR004178; CaM-bd_dom.
DR   InterPro; IPR036122; CaM-bd_dom_sf.
DR   InterPro; IPR015449; K_chnl_Ca-activ_SK.
DR   InterPro; IPR013099; K_chnl_dom.
DR   PANTHER; PTHR10153:SF41; INTERMEDIATE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 4; 1.
DR   PANTHER; PTHR10153; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL; 1.
DR   Pfam; PF02888; CaMBD; 1.
DR   Pfam; PF07885; Ion_trans_2; 1.
DR   Pfam; PF03530; SK_channel; 1.
DR   SMART; SM01053; CaMBD; 1.
DR   SUPFAM; SSF81327; Small-conductance potassium channel; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   2: Evidence at transcript level;
KW   Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        25..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        176..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        230..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          273..346
FT                   /note="Calmodulin-binding"
FT                   /evidence="ECO:0000259|SMART:SM01053"
SQ   SEQUENCE   395 AA;  44322 MW;  D825B43180CEB1D5 CRC64;
     MGGELVTGLG ALRRRKRLLE QEKRVAGWAL VLAGTGIGLM VLHAEMLWFL GCKEVQLFMT
     DNGLRDWRVA LTRRQVAQIL LELLVCGVHP VPLRSPHCTL AGEATDSQAW PGFLGEGEAL
     LSLAMLLRLY LVPRAVLLRS GVLLNASYRS IGALNQVRFR HWFVAKLYMN THPGRLLLGL
     TLGLWLTTAW VLSVAERQAV NATGHLTDTL WLIPITFLTI GYGDVVPGTL WGKIVCLCTG
     VMGVCCTALL VAVVARKLEF NKAEKHVHNF MMDIHYAKEM KESAARLLQE AWMYYKHTRR
     KDSRAARRHQ RKMLAAIHTF RQVRLKHRKL REQVNSMVDI SKMHMILCDL QLGLSASHLA
     LEKRIDGLAG KLDALTELLS TALQQQPPEP IQEAT
//
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