ID   C7BBR9_9NEOB            Unreviewed;       229 AA.
AC   C7BBR9;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=Chemokine receptor 4 {ECO:0000313|EMBL:ACT20985.1};
DE   Flags: Fragment;
GN   Name=CXCR4 {ECO:0000313|EMBL:ACT20985.1};
OS   Duttaphrynus stuarti (Stuart's toad).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Bufonidae; Duttaphrynus.
OX   NCBI_TaxID=655862 {ECO:0000313|EMBL:ACT20985.1};
RN   [1] {ECO:0000313|EMBL:ACT20985.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=1936DuSt {ECO:0000313|EMBL:ACT20985.1};
RA   Bossuyt F., Van Bocxlaer I., Biju S.D., Loader S.P.;
RT   "Toad radiation reveals into-India dispersal as a source of endemism in the
RT   Western Ghats-Sri Lanka biodiversity hotspot.";
RL   Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|RuleBase:RU000688}.
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DR   EMBL; FJ882689; ACT20985.1; -; Genomic_DNA.
DR   AlphaFoldDB; C7BBR9; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR001277; CXCR4/ACKR2.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   PANTHER; PTHR10489:SF594; C-X-C CHEMOKINE RECEPTOR TYPE 4; 1.
DR   PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00645; CXCCHMKINER4.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:ACT20985.1};
KW   Transducer {ECO:0000256|RuleBase:RU000688};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000688};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        38..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        128..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        170..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..229
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACT20985.1"
FT   NON_TER         229
FT                   /evidence="ECO:0000313|EMBL:ACT20985.1"
SQ   SEQUENCE   229 AA;  26056 MW;  C27191554E07F0E6 CRC64;
     RLHLSVADLL FVFTLPFWSV DAAIGWYFKE FLCKAVHVIY TVNLYSSVLI LAFISLDRYL
     AIVHATNSQG SRKLLAEKIV YAGVWLPAIL LTVPDVVFAS VSDIEGNFVC DRIYPVANRE
     HWTIGFRFLH ITVGLILPGL IILTCYCVII SKLSHSKGHQ KRKALKTTVI LILAFFACWL
     PYYICLTIDT FGLLGLLKFD CYMDNTLHKW ISITEALAFF HCCLNPILY
//