ID   C7CAH1_METED            Unreviewed;       811 AA.
AC   C7CAH1;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   RecName: Full=Probable phosphoketolase {ECO:0000256|HAMAP-Rule:MF_01403};
DE            EC=4.1.2.- {ECO:0000256|HAMAP-Rule:MF_01403};
GN   Name=xfp {ECO:0000313|EMBL:CAX22196.1};
GN   ORFNames=METD_I0539 {ECO:0000313|EMBL:CAX22196.1};
OS   Methylorubrum extorquens (strain DSM 6343 / CIP 106787 / DM4)
OS   (Methylobacterium extorquens).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Methylobacteriaceae; Methylorubrum.
OX   NCBI_TaxID=661410 {ECO:0000313|EMBL:CAX22196.1, ECO:0000313|Proteomes:UP000008070};
RN   [1] {ECO:0000313|Proteomes:UP000008070}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 6343 / CIP 106787 / DM4
RC   {ECO:0000313|Proteomes:UP000008070};
RX   PubMed=19440302; DOI=10.1371/journal.pone.0005584;
RA   Vuilleumier S., Chistoserdova L., Lee M.-C., Bringel F., Lajus A., Zhou Y.,
RA   Gourion B., Barbe V., Chang J., Cruveiller S., Dossat C., Gillett W.,
RA   Gruffaz C., Haugen E., Hourcade E., Levy R., Mangenot S., Muller E.,
RA   Nadalig T., Pagni M., Penny C., Peyraud R., Robinson D.G., Roche D.,
RA   Rouy Z., Saenampechek C., Salvignol G., Vallenet D., Wu Z., Marx C.J.,
RA   Vorholt J.A., Olson M.V., Kaul R., Weissenbach J., Medigue C.,
RA   Lidstrom M.E.;
RT   "Methylobacterium genome sequences: a reference blueprint to investigate
RT   microbial metabolism of C1 compounds from natural and industrial sources.";
RL   PLoS ONE 4:E5584-E5584(2009).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964,
CC         ECO:0000256|HAMAP-Rule:MF_01403};
CC   -!- SIMILARITY: Belongs to the XFP family. {ECO:0000256|ARBA:ARBA00005623,
CC       ECO:0000256|HAMAP-Rule:MF_01403}.
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DR   EMBL; FP103042; CAX22196.1; -; Genomic_DNA.
DR   RefSeq; WP_015821017.1; NC_012988.1.
DR   AlphaFoldDB; C7CAH1; -.
DR   GeneID; 72987856; -.
DR   KEGG; mdi:METDI0539; -.
DR   HOGENOM; CLU_013954_2_0_5; -.
DR   Proteomes; UP000008070; Chromosome.
DR   GO; GO:0016832; F:aldehyde-lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   CDD; cd02011; TPP_PK; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   HAMAP; MF_01403; Phosphoketolase; 1.
DR   InterPro; IPR023962; Phosphoketolase.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005593; Xul5P/Fru6P_PKetolase.
DR   InterPro; IPR018969; Xul5P/Fru6P_PKetolase_C.
DR   InterPro; IPR019790; Xul5P/Fru6P_PKetolase_CS.
DR   InterPro; IPR018970; Xul5P/Fru6P_PKetolase_N.
DR   InterPro; IPR019789; Xul5P/Fru6P_PKetolase_ThDP_BS.
DR   PANTHER; PTHR31273; PHOSPHOKETOLASE-RELATED; 1.
DR   PANTHER; PTHR31273:SF0; PHOSPHOKETOLASE-RELATED; 1.
DR   Pfam; PF03894; XFP; 1.
DR   Pfam; PF09363; XFP_C; 1.
DR   Pfam; PF09364; XFP_N; 1.
DR   PIRSF; PIRSF017245; Phosphoketolase; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   PROSITE; PS60002; PHOSPHOKETOLASE_1; 1.
DR   PROSITE; PS60003; PHOSPHOKETOLASE_2; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_01403};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052, ECO:0000256|HAMAP-
KW   Rule:MF_01403}.
FT   DOMAIN          21..380
FT                   /note="Xylulose 5-phosphate/Fructose 6-phosphate
FT                   phosphoketolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF09364"
FT   DOMAIN          597..799
FT                   /note="Xylulose 5-phosphate/Fructose 6-phosphate
FT                   phosphoketolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF09363"
SQ   SEQUENCE   811 AA;  90879 MW;  7C0DDAA599B445CC CRC64;
     MTEPTNTQGR TAPSSATLGG EELALIDRYW QAANYLSVGQ IYLLDNPLLR EPLQPQHIKS
     RLLGHWGTTP GLNFIYVHLN RLIKARDLDA IYICGPGHGG PGIVANTYLE GTYSEVYPDI
     AQDTEGMRRL FRQFSFPGGI PSHVAPETPG SIHEGGELGY AIVHAFGAVF DNPDLIAACV
     IGDGEAETGP LAASWQSNKF LGPVTDGAVL PILHLNGYKI ANPTVLGRMR DDELESLFTG
     FGYEPLFVEG DQPEPMHRAM AEALDRAVAR IKDIQAEARG GGMGFRRPRW PMIVLRSPKG
     WTGPKTVDGK RVEGFWRAHQ VPVGNARTDD RHRQILEDWM RSYRPETLFD ETGRLRPELA
     ALAPEGNRRM SANPHANGGL LRRELRVPRW QDFALTVSKP GAEIGEATRT LGRYLRDVIR
     LNAEARNFRI MGPDETASNR LDAVFEATDR VWIENIEPYD VSLAHEGRVM EVLSEHLCQG
     WLEGYLLTGR HGLFSCYEAF IHIVDSMFNQ HAKWLKVSRE LGWRRPISSL NYLLTSHVWR
     QDHNGFSHQD PGFIDLVANK KSDIVRVYLP PDANTLLWVA DHCLQTYDRI NVIVAGKQPQ
     PQWLSAHEAG LHCEAGIGIW SWAGTDETGL EPDVVMACAG DVPTLETLAA VDLLKQAVPG
     LRIRVVNVVD LMTLQSNRDH PHGLTDAAFD SLFTRDKPVI FAYHGYPYLI HRLTYSRANH
     ANMHVRGFIE EGTTTTPFDM VVLNELDRFH LAIEAIDRVP GLVTRAAGAK QAFRDRLTAH
     KLYIREHGED MPEIQGWKWP YETRQETGTP H
//