ID C7DQU6_ORYLA Unreviewed; 372 AA.
AC C7DQU6;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=DND microRNA-mediated repression inhibitor 1 {ECO:0000313|Ensembl:ENSORLP00000029898.1};
DE SubName: Full=Dead end protein {ECO:0000313|EMBL:ACU33922.1};
GN Name=Dnd {ECO:0000313|EMBL:ACU33922.1};
GN Synonyms=dnd1 {ECO:0000313|Ensembl:ENSORLP00000029898.1};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|EMBL:ACU33922.1};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000029898.1, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000029898.1,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|EMBL:ACU33922.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I3 {ECO:0000313|EMBL:ACU33922.1};
RC TISSUE=Ovary {ECO:0000313|EMBL:ACU33922.1};
RX PubMed=19577665; DOI=10.1016/j.gep.2009.06.008;
RA Liu L., Hong N., Xu H., Li M., Yan Y., Purwanti Y., Yi M., Li Z., Wang L.,
RA Hong Y.;
RT "Medaka dead end encodes a cytoplasmic protein and identifies embryonic and
RT adult germ cells.";
RL Gene Expr. Patterns 9:541-548(2009).
RN [3] {ECO:0000313|Ensembl:ENSORLP00000029898.1}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000029898.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; GQ184560; ACU33922.1; -; mRNA.
DR RefSeq; NP_001157988.1; NM_001164516.1.
DR STRING; 8090.ENSORLP00000029898; -.
DR Ensembl; ENSORLT00000046497.1; ENSORLP00000029898.1; ENSORLG00000025449.1.
DR GeneID; 100302723; -.
DR KEGG; ola:100302723; -.
DR CTD; 373863; -.
DR GeneTree; ENSGT00940000159225; -.
DR OrthoDB; 3184171at2759; -.
DR Proteomes; UP000001038; Chromosome 10.
DR Bgee; ENSORLG00000025449; Expressed in ovary and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043073; C:germ cell nucleus; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043186; C:P granule; IEA:Ensembl.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:Ensembl.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0007281; P:germ cell development; IEA:Ensembl.
DR GO; GO:0008354; P:germ cell migration; IEA:Ensembl.
DR GO; GO:0060047; P:heart contraction; IEA:Ensembl.
DR GO; GO:0048255; P:mRNA stabilization; IBA:GO_Central.
DR GO; GO:0060965; P:negative regulation of miRNA-mediated gene silencing; IBA:GO_Central.
DR GO; GO:2000145; P:regulation of cell motility; IEA:Ensembl.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR21245:SF4; DEAD END PROTEIN HOMOLOG 1; 1.
DR PANTHER; PTHR21245; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; 1.
DR Pfam; PF14709; DND1_DSRM; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50137; DS_RBD; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 52..130
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 287..367
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT REGION 212..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 372 AA; 40328 MW; 5D0A4746A8ADAB8F CRC64;
MDNQSKVVNL ERVQALQAWV KSTNTKLTQV NGQRKYGGPP DVWDGPPPGA RCEVFISQIP
RDVYEDLLIP LFSSVGALWE FRLMMNFSGQ NRGFAYAKYG TAAIANDAIH LLHGYPLGPG
ARLSVRCSIE KRQLCIQNLP ASTRQEELLQ VLRLLSAGVE SVALKAGPGI EGVSAVVAFS
SHHAASMAKK ALGEEFKKQF CLDISIKWLS AEKPNPDKPP PQRAPKGLLP SPLKHLGQTS
PRLPPRLASP AVPTAFCKAV GGPPTQHDTH VKGTSPPPRG QVMFSVSPVL LLRKLSEASG
WGDPHYEMLF SHAGPDGFLY FTYKVHVPGA PTTFRGFVMI LPGHCTSTML EEARRAAAQQ
VLQKLCSSGL SA
//
