ID   C7E0Q2_CULPP            Unreviewed;       135 AA.
AC   C7E0Q2;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Putative 3-hydroxyacyl-CoA dehyrogenase {ECO:0000313|EMBL:ACT32987.1};
DE   Flags: Fragment;
GN   Name=HCDH-2 {ECO:0000313|EMBL:ACT32987.1};
OS   Culex pipiens pipiens (Northern house mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=38569 {ECO:0000313|EMBL:ACT32987.1};
RN   [1] {ECO:0000313|EMBL:ACT32987.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Sim C., Denlinger D.L.;
RT   "Transcription profiling and regulation of fat metabolism genes in
RT   diapausing adults of the mosquito Culex pipiens.";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC       {ECO:0000256|ARBA:ARBA00004305}.
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DR   EMBL; GQ232422; ACT32987.1; -; mRNA.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43561; -; 1.
DR   PANTHER; PTHR43561:SF3; HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   2: Evidence at transcript level;
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128}.
FT   DOMAIN          1..71
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          73..132
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACT32987.1"
FT   NON_TER         135
FT                   /evidence="ECO:0000313|EMBL:ACT32987.1"
SQ   SEQUENCE   135 AA;  14714 MW;  0E965897F612789A CRC64;
     FVSNTSSLSI VELGSVTKRE DRFAGFHFFN PVPLMRLVEV IKTDKTSEET NASLLAFGGA
     LGKTCISCKD TPGFIVNRLL LTIISEALGM LERGDASLKD IDTALKLGLG HPMGPFELMD
     MIGLXVTLNI MQERQ
//