ID C7F835_9HIV2 Unreviewed; 258 AA.
AC C7F835;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:ACT85839.1};
OS Human immunodeficiency virus 2.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11709 {ECO:0000313|EMBL:ACT85839.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ACT85839.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NARI-H2-13 {ECO:0000313|EMBL:ACT85839.1};
RA Jadhav S.D., Tripathy S.P., Kulkarni S.S., Chaturbhuj D.N., Ghare R.A.,
RA Bhattacharya J., Paranjape R.S.;
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACT85839.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NARI-H2-13 {ECO:0000313|EMBL:ACT85839.1};
RX PubMed=21453135; DOI=10.1089/aid.2011.0063;
RA Jadhav S., Tripathy S., Kulkarni S., Chaturbhuj D., Ghare R.,
RA Bhattacharya J., Paranjape R.;
RT "Genetic Conservation in gp36 Transmembrane Sequences of Indian HIV Type 2
RT Isolates.";
RL AIDS Res. Hum. Retroviruses 27:1337-1343(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; GQ338301; ACT85839.1; -; Genomic_DNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:ACT85839.1};
KW Virion {ECO:0000313|EMBL:ACT85839.1}.
FT TRANSMEM 168..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..214
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT COILED 112..139
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACT85839.1"
FT NON_TER 258
FT /evidence="ECO:0000313|EMBL:ACT85839.1"
SQ SEQUENCE 258 AA; 29881 MW; 633D70CFE08AF563 CRC64;
GVFVLGFLGF LTTAGAAMGA ASLTLSAQSR TLLAGIVQQQ QQLLDVVKRQ QEMLRLTVWG
TKNLQARVTA IEKYLKDQAQ LNSWGCAFRQ VCHTTVPWVN DSITPNWNNM TWQEWEQQVR
FLEANISQSL EEAQIQQEKN MYELQKLNSW DVFGNWFDLT SWIKYIQYGV YIIVGIIVLR
IVIYVVQMLS RLREGYRPVF SSPPGYIQQI HIHKDQGQPA REETEEDVGS DGGYSSWPWP
IEYIHFLIRQ LIRLLNRL
//
